Improved outcome of resection of hilar cholangiocarcinoma (Klatskin tumor)

Annals of Surgical Oncology
Sander DinantThomas M van Gulik

Abstract

Treatment of hilar cholangiocarcinoma (Klatskin tumors) has changed in many aspects. A more extensive surgical approach, as proposed by Japanese surgeons, has been applied in our center over the last 5 years; it combines hilar resection with partial hepatectomy for most tumors. The aim of this study was to assess the outcome of a 15-year evolution in the surgical treatment of Klatskin tumors. A total of 99 consecutive patients underwent resection for hilar cholangiocarcinoma in three 5-year time periods: periods 1 (1988-1993; n=45), 2 (1993-1998; n=25), and 3 (1998-2003; n=29). Outcome was evaluated by assessment of completeness of resection, postoperative morbidity and mortality, and survival. The proportion of margin negative resections increased significantly from 13% in period 1 to 59% in period 3 (P<.05). Two-year survival increased significantly from 33%+/-7% and 39%+/-10% in periods 1 and 2 to 60%+/-11% in period 3 (P<.05). Postoperative morbidity and mortality were considerable but did not increase with this changed surgical strategy (68% and 10%, respectively, in period 3). Lymph node metastasis was, next to period of resection, also associated with survival in univariate analysis. Mainly in the last 5-year period (199...Continue Reading

References

Mar 1, 1995·Archives of Surgery·W K WashburnR L Jenkins
Jan 1, 1993·Annals of Surgery·H U BaerL H Blumgart
Jan 1, 1993·Endoscopy·T L TioG N Tytgat
Nov 1, 1996·Annals of Surgery·R PichlmayrB Ringe
Jan 1, 1997·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·O M van DeldenJ W Reeders
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J KlempnauerR Pichlmayr
Feb 14, 1998·The British Journal of Surgery·Y Ogura, Y Kawarada
Dec 5, 1998·World Journal of Surgery·M F GerhardsD J Gouma
Sep 12, 2000·Journal of Hepato-biliary-pancreatic Surgery·Y NimuraN Hayakawa
Oct 4, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M F GerhardsD J Gouma
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J FiguerasE Jaurrieta
Feb 13, 2001·The British Journal of Surgery·E K AbdallaJ N Vauthey
Sep 27, 2001·Annals of Surgery·W R JarnaginL H Blumgart
Oct 13, 2001·World Journal of Surgery·M NaginoY Nimura
May 23, 2002·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Esther H B M TillemanDirk J Gouma
Nov 20, 2002·Journal of the American College of Surgeons·Lorenzo CapussottiPaolo Massucco
Mar 5, 2003·World Journal of Surgery·Michael F GerhardsDirk J Gouma
Aug 7, 2003·American Journal of Clinical Oncology·Dwight E HeronPramila Rani Anne

❮ Previous
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Citations

Jul 19, 2013·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Anthony T RuysThomas M van Gulik
Dec 7, 2013·World Journal of Surgery·Norihiko FurusawaSin-ichi Miyagawa
Apr 25, 2007·Annals of Surgical Oncology·Thomas M van Gulik, Dirk J Gouma
Aug 16, 2014·American Journal of Surgery·Patryk Kambakamba, Michelle L DeOliveira
Jun 10, 2014·International Journal of Surgery·Mohamed AbdelwahabKhaleed Zalata
Dec 7, 2013·Cardiovascular and Interventional Radiology·Dominik GeiselBernhard Gebauer
May 10, 2012·World Journal of Surgery·Anthony T RuysThomas M van Gulik
May 21, 2014·Langenbeck's Archives of Surgery·Irinel Popescu, Traian Dumitrascu
Apr 26, 2007·Annals of Surgery·Michelle L DeOliveiraRichard D Schulick
Sep 3, 2008·World Journal of Gastroenterology : WJG·Jaap Jacob KloekThomas Mathijs van Gulik
Apr 17, 2009·World Journal of Gastroenterology : WJG·Zheng ShiYou-Ting Chen
Sep 15, 2009·World Journal of Gastroenterology : WJG·Murad AljiffryMichele Molinari
May 24, 2011·World Journal of Clinical Oncology·Nobuhisa AkamatsuDaijo Hashimoto
Jul 28, 2007·Digestive Surgery·Deha ErdoganThomas M van Gulik
May 5, 2011·Digestive Surgery·Thomas M van GulikDirk J Gouma
Jan 29, 2013·World Journal of Surgery·Jin Hong LimWoo Jung Lee
Jul 2, 2010·Annals of Surgical Oncology·Stéphane GrandadamKarim Boudjema
Apr 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N A van der GaagT M van Gulik
Dec 26, 2012·Journal of the American College of Surgeons·Andrew P LoehrerHenry A Pitt
Sep 21, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Q-B ChengB-H Zhang
Jul 4, 2012·Journal of the American College of Surgeons·Kenichi MatsuoWilliam R Jarnagin
Jul 29, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Chris D MannDavid P Berry
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·J J KloekT M van Gulik
Sep 6, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·L CapussottiA Muratore
Aug 29, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jan GrendarElijah Dixon
Apr 6, 2011·Journal of the American College of Surgeons·Johnny C HongRonald W Busuttil
Mar 25, 2009·Surgical Oncology Clinics of North America·Yasuji SeyamaMasatoshi Makuuchi
Feb 21, 2009·Journal of the American College of Surgeons·Murad AljiffryMichele Molinari
Aug 19, 2007·Current Problems in Surgery·Sean P ClearySteven Gallinger
Sep 10, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christopher R ShubertDavid M Nagorney
Aug 15, 2015·International Journal of Surgery·Hong-qiang YangXiao-ping Chen
Apr 14, 2012·The Mount Sinai Journal of Medicine, New York·Manoj K Singh, Marcelo E Facciuto
Oct 28, 2009·Journal of Hepato-biliary-pancreatic Sciences·Alastair L YoungJ Peter A Lodge
Sep 22, 2011·Alimentary Pharmacology & Therapeutics·J R A SkipworthM Malagó
Nov 27, 2009·Journal of Hepato-biliary-pancreatic Sciences·Michiaki UnnoShinichi Egawa

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