Improved Outcomes Following Hepatocellular Carcinoma (HCC) Diagnosis in Patients Screened for HCC in a Large Academic Liver Center versus Patients Identified in the Community

Journal of Clinical and Translational Hepatology
Nneoma OkoronkwoNikolaos Pyrsopoulos

Abstract

Background and Aims: Hepatocellular carcinoma (HCC) is the sixth most commonly occurring cancer worldwide. Knowledge and adherence to HCC surveillance guidelines has been associated with earlier detection. We sought to evaluate characteristics and outcomes following HCC diagnosis in patients screened for HCC in a large academic liver center versus patients diagnosed and referred from the community. Methods: We reviewed the records of patients diagnosed with HCC in the liver center of an academic institution from January 1999 till December 2013. Patients were classified into two groups: patients followed in our hepatology clinic and patients with HCC recently referred to our center. Univariate analysis was performed using chi-squared test and multivariate analysis was performed using SPSS 22.0. Results: The records of 410 patients were reviewed, and included 77.3% of patients referred from the community and 22.7% of patients followed in our clinic. In the clinic group, 75.6% were identified with one nodule at initial diagnosis, compared to 65.6% in the referral group. Patients in the referral group were more likely to present with tumors ≥5 cm at diagnosis, with 28.7% compared to 5.4% in the clinic group (p < 0.0001). Patients r...Continue Reading

References

Sep 22, 1999·Journal of General Internal Medicine·L R HarroldJ H Gurwitz
Dec 18, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Tammy T ChangCarlos U Corvera
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jessica A DavilaHashem B El-Serag
Dec 9, 2010·The Oncologist·Alan P VenookLaura Ladrón de Guevara
Dec 7, 2010·Journal of Gastroenterology and Hepatology·Yao-Li ChenHung-Wen Lai
Feb 15, 2011·Therapeutic Advances in Gastroenterology·Hashem B El-Serag, Jessica A Davila
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN American Association for the Study of Liver Diseases
Jun 23, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vincenzo MazzaferroLuigi Mariani
Aug 1, 2012·Cancer Prevention Research·Amit G SingalJasmin A Tiro
May 2, 2013·Journal of Clinical Gastroenterology·Sahil Mittal, Hashem B El-Serag
Jul 6, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Susanna V UlahannanSean F Altekruse
Jan 23, 2013·Clinical Liver Disease·Robert S RahimiAmit G Singal

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Methods Mentioned

BETA
surgical resection

Software Mentioned

Statistical Package for the Social Sciences

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