PMID: 8606885Nov 1, 1995Paper

Improved parameters for risk estimation in Down's syndrome screening

Prenatal Diagnosis
H S Cuckle

Abstract

A new method is described for calculating maternal serum marker distribution parameters which will improve risk estimation when screening for Down's syndrome. The approach is to calculate parameters using data from the local screened population and data obtained by meta-analysis from all published studies. The local data are used to derive the variance and covariance in unaffected pregnancies. The meta-analysis is used for the mean level in Down's syndrome pregnancies together with the differences in variance and covariance between affected and unaffected pregnancies. Forty-four published studies were analysed. The mean level for Down's syndrome in multiples of the normal median was 0.73 for alpha-fetoprotein (AFP) in total of 1140 pregnancies, 0.73 for unconjugated oestriol (uE3) in 613, 2.02 for human chorionic gonadotropin (hCG) in 850, and 2.30 for free beta-hCG in 477. For all four markers, the variance in Down's syndrome was higher than in unaffected pregnancies; for AFP and uE3, the covariances were also higher in Down's syndrome, but for the other markers they were lower. The method was illustrated using data from 6387 pregnancies screened in Leeds.

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Citations

Jul 23, 1999·Prenatal Diagnosis·H S Cuckle, J M van Lith
Nov 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H S CuckleS Holding
Jun 1, 2005·Clinics in Perinatology·Melissa C Bush, Fergal D Malone
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·R YamamotoS Fujimoto
Jul 24, 2002·Clinica Chimica Acta; International Journal of Clinical Chemistry·Peter A Benn
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Dec 30, 1996·Early Human Development·H Cuckle
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Oct 10, 2003·The New England Journal of Medicine·Ronald WapnerUNKNOWN First Trimester Maternal Serum Biochemistry and Fetal Nuchal Translucency Screening (BUN) Study Group
Apr 24, 2001·Current Opinion in Obstetrics & Gynecology·H Cuckle
Aug 2, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Glenn E PalomakiJoEllen Lee
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Nov 11, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·José Antonio SainzRogelio Garrido
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Dec 24, 2003·Prenatal Diagnosis·Françoise MullerUNKNOWN French Collaborative Group
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May 1, 2007·Prenatal Diagnosis·Michael ChristiansenUlla M Wewer
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