Improved pharmacokinetics and enhanced tumor growth inhibition using a nanostructured lipid carrier loaded with doxorubicin and modified with a layer-by-layer polyelectrolyte coating

International Journal of Pharmaceutics
Samuel V MussiVladimir Torchilin

Abstract

A nanostructured lipid carrier (NLC) loaded with doxorubicin (DOX) has been shown to be cytotoxic against the human cancer cell lines A549 and MCF-7/Adr. In attempts to improve formulation characteristics, enhance pharmacokinetics and antitumor effects, we modified the surface of these NLC with an alternating layer-by-layer (LbL) assembly of polycation and polyanion polyelectrolytes and an additional coating with PEG using a simple method of core shell attachment. The formulation had a narrow size distribution, longer residence in the blood, lower accumulation in the liver, higher accumulation in tumors and a significant tumor growth inhibition effect. Thus, NLC-DOX nanopreparations complexes modified by LbL coating have the potential to enhance the anticancer effects of DOX against tumors.

References

Aug 15, 2002·International Journal of Pharmaceutics·R H MüllerS A Wissing
Nov 10, 2006·Advanced Drug Delivery Reviews·Vladimir P Torchilin
Jul 1, 2008·International Journal of Pharmaceutics·Xing-Guo ZhangFu-Qiang Hu
Oct 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Medha D Joshi, Rainer H Müller
Nov 28, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Samuel Vidal MussiLucas Antônio Miranda Ferreira
Sep 14, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Tao WangVladimir P Torchilin
Feb 11, 2014·Carbohydrate Polymers·Thiruganesh RamasamyJong Oh Kim
Feb 11, 2014·International Journal of Pharmaceutics·Gaurav ParekhYuri Lvov

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Citations

May 4, 2018·Therapeutic Delivery·Gaurav ParekhStefano Leporatti
Jun 7, 2019·Chemistry, an Asian Journal·Katsuhiko ArigaByeong-Su Kim
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Marjan MotieiSeyede Zohreh Mirahmadi-Zare

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