Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching

Proteins
P D AdamsA T Brünger

Abstract

A more global search method, using fewer assumptions, has been used to predict the structure of the dimeric transmembrane region of the protein glycophorin A. The resulting model significantly differs from that previously determined. In particular, the arrangement between the two transmembrane helices is now more symmetric resulting in improved interaction energies and an increased buried surface area. An increase in the van der Waals interaction energy due to tighter packing compensates for the loss of the interhelical hydrogen bond observed between Thr-87 of each helix in the previous model.

References

Dec 29, 1992·Biochemistry·M A LemmonD M Engelman
May 1, 1990·Biochemistry·J L Popot, D M Engelman
Jan 5, 1981·Journal of Molecular Biology·C ChothiaD Richardson
Mar 1, 1994·Nature Structural Biology·M A LemmonD M Engelman
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·S O Smith, B J Bormann
May 1, 1994·Quarterly Reviews of Biophysics·M A Lemmon, D M Engelman

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Citations

Oct 9, 2012·The Journal of Chemical Physics·Satoshi YasudaMasahiro Kinoshita
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·W P Russ, D M Engelman
Jul 13, 2000·Protein Science : a Publication of the Protein Society·M OrzáezI Mingarro
Nov 21, 2001·Protein Science : a Publication of the Protein Society·T J Stevens, I T Arkin
Jun 19, 2002·Protein Science : a Publication of the Protein Society·Kay E GottschalkHorst Kessler
Jan 13, 2000·Protein Science : a Publication of the Protein Society·J U Bowie
Jan 24, 2007·Acta Crystallographica. Section D, Biological Crystallography·Pavel StropAxel T Brunger
Feb 20, 2009·The Journal of Biological Chemistry·Bradley E PoulsenCharles M Deber
Jul 22, 2009·The Journal of Experimental Medicine·Isabelle PloStéphane de Botton
Oct 29, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ting PangRy Young
Jul 14, 2010·The Journal of Biological Chemistry·Lijuan HeKalina Hristova
Mar 16, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Erin E MatthewsDonald M Engelman
Mar 3, 2010·Journal of Molecular Modeling·Siti Azma JusohVolkhard Helms
Dec 22, 1999·Annals of the New York Academy of Sciences·P D AdamsD M Engelman
Aug 18, 2009·Chemistry and Physics of Lipids·Natalie Bordag, Sandro Keller
Mar 16, 2005·Proteins·Vikas Nanda, William F DeGrado
Jun 17, 2009·Protein Science : a Publication of the Protein Society·Dieter Langosch, Isaiah T Arkin
May 22, 2004·European Journal of Biochemistry·Visvaldas KairysBurkhard Luy
Jul 2, 2003·Proteins·Themis Lazaridis
Jan 6, 2006·Proteins·Madhusoodanan MottamalThemis Lazaridis
Feb 22, 2007·Proteins·Douglas G MetcalfWilliam F DeGrado
Jun 24, 2010·Protein Science : a Publication of the Protein Society·Kuei-Min ChungXin Chen
Sep 6, 2011·The EMBO Journal·Judith StaerkStefan N Constantinescu
Aug 3, 2007·Biochimica Et Biophysica Acta·Evgenia GlukhovRichard M Epand
Aug 18, 2004·Current Opinion in Structural Biology·Alessandro SenesWilliam F DeGrado
Oct 19, 2001·Biophysical Journal·J TorresI T Arkin
Nov 3, 2004·Biochimica Et Biophysica Acta·Walter L AshD Peter Tieleman
Jul 27, 2010·Biophysical Journal·Lorant JanosiManolis Doxastakis
Aug 28, 2004·Journal of Molecular Graphics & Modelling·Kay-Eberhard Gottschalk
May 5, 2004·Journal of Molecular Biology·Doron GerberYechiel Shai
Jan 13, 2006·Trends in Biochemical Sciences·Sarel J FleishmanNir Ben-Tal
Jan 24, 2006·Journal of Molecular Biology·Abigail E Kroch, Karen G Fleming
Dec 31, 2005·Journal of Molecular Biology·Edwin LiKalina Hristova
Jun 17, 2009·Journal of Molecular Biology·Douglas G MetcalfWilliam F DeGrado

❮ Previous
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