Improved prediction of disturbed flow via hemodynamically-inspired geometric variables.

Journal of Biomechanics
Payam B BijariDavid A Steinman

Abstract

Arterial geometry has long been considered as a pragmatic alternative for inferring arterial flow disturbances, and their impact on the natural history and treatment of vascular diseases. Traditionally, definition of geometric variables is based on convenient shape descriptors, with only superficial consideration of their influence on flow and wall shear stress patterns. In the present study we demonstrate that a more studied consideration of the actual (cf. nominal) local hemodynamics can lead to substantial improvements in the prediction of disturbed flow by geometry. Starting from a well-characterized computational fluid dynamics (CFD) dataset of 50 normal carotid bifurcations, we observed that disturbed flow tended to be confined proximal to the flow divider, whereas geometric variables previously shown to be significant predictors of disturbed flow included features distal to the flow divider in their definitions. Flaring of the bifurcation leading to flow separation was redefined as the maximum relative expansion of the common carotid artery (CCA), proximal to the flow divider. The beneficial effect of primary curvature on flow inertia, via suppression of flow separation, was characterized by the in-plane tortuosity of CC...Continue Reading

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Citations

Apr 23, 2013·Annals of Biomedical Engineering·Trung B LeFotis Sotiropoulos
Nov 2, 2014·Annual Review of Fluid Mechanics·John M TarbellHanjoong Jo
Apr 22, 2014·Journal of Biomechanics·J T C SchrauwenF J H Gijsen
Jan 8, 2016·Thrombosis and Haemostasis·Umberto MorbiducciJolanda J Wentzel
Nov 19, 2015·Medical & Biological Engineering & Computing·Yimin ChenBernard Chiu
Aug 3, 2012·Journal of Biomechanics·Diego GalloUmberto Morbiducci
May 9, 2014·Journal of Hypertension·Jelle BossuytErnst Rietzschel
Feb 8, 2018·Vascular and Endovascular Surgery·Matthew G DoyleThomas L Forbes
Feb 22, 2018·The International Journal of Cardiovascular Imaging·Sekou GreggAmer M Johri
Dec 21, 2013·Stroke; a Journal of Cerebral Circulation·Payam B BijariDavid A Steinman
Sep 23, 2014·Annals of Biomedical Engineering·Diego GalloUmberto Morbiducci
Jan 20, 2019·Annals of Biomedical Engineering·Maurizio DomaninUmberto Morbiducci

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