Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Filiberto Cedeno-LaurentAlain H Rook

Abstract

Pruritus is one of the cardinal symptoms found in patients with leukemic cutaneous T cell lymphoma (CTCL). The nature of the pruritus experienced by CTCL patients is complex, involving different pathways and cell mediators, thus making it poorly responsive to conventional anti-itch therapies. Recent reports highlight the role of interleukin 31 (IL-31) as a novel cytokine involved in the pathogenesis of pruritus in atopic dermatitis and CTCL. Here we provide both in vivo and in vitro evidence suggesting that histone deacetylase (HDAC) inhibitors may mitigate itch through lowering of levels of IL-31-expressing T cells. Furthermore, we demonstrate that chemokine receptor type-4 (CCR4)-bearing T cells are a main source of IL-31 in CTCL, and that neutralizing the IL-31 pathway through targeting of the CCR4-expressing T cells may represent a promising therapeutic strategy for symptomatic relief in CTCL.

References

Jun 1, 1988·The Keio Journal of Medicine·P W Heald, R L Edelson
Dec 18, 2002·The Journal of Investigative Dermatology·Katalin FerencziThomas S Kupper
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Eniko SonkolyBernhard Homey
Aug 12, 2006·Current Oncology Reports·Ellen J KimAlain H Rook
Apr 18, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bhupinder S MannRichard Pazdur
Jan 31, 2012·Journal of the American Academy of Dermatology·Kristen AhernBrian Poligone
Mar 16, 2012·Future Medicinal Chemistry·Sophia RangwalaMadeleine Duvic
Apr 19, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ulrike RaapRegina Fölster-Holst
May 24, 2013·The Journal of Investigative Dermatology·Elisha M SingerAlain H Rook
Jun 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emmanuella GuenovaRachael A Clark
Mar 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michinori OguraRyuzo Ueda

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Citations

Dec 3, 2015·Expert Opinion on Pharmacotherapy·Carolyn StullGil Yosipovitch
Sep 30, 2015·European Journal of Pain : EJP·B Rowe, G Yosipovitch
Oct 5, 2015·Dermatologic Clinics·Larisa J Geskin
Jul 8, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Schmid-WendtnerC-M Wendtner
Jun 19, 2016·The British Journal of Dermatology·S Schreml
Aug 4, 2016·The British Journal of Dermatology·J J Scarisbrick
Aug 25, 2016·The Journal of Allergy and Clinical Immunology·Amy S PallerEmma Guttman-Yassky
Nov 30, 2016·Experimental Dermatology·Brittany DulmageOleg E Akilov
May 19, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·D J LewisM Duvic
Jan 29, 2019·Current Topics in Medicinal Chemistry·Yu BaiGuihua Cui
Apr 26, 2019·Experimental Dermatology·Argentina LeonGil Yosipovitch
Dec 24, 2019·Physiological Reviews·Ferda Cevikbas, Ethan A Lerner
Sep 29, 2020·Veterinary Dermatology·Nataliia IgnatenkoRalf S Mueller
Apr 15, 2017·Journal of Leukocyte Biology·Elisa FerrettiVito Pistoia
Mar 8, 2017·Pediatric Allergy, Immunology, and Pulmonology·Franziska RosserJuan C Celedón
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Veronica StolearencoThorbjørn Krejsgaard
Jun 20, 2018·Frontiers in Oncology·Kazuyasu Fujii
May 26, 2020·Pharmacology & Therapeutics·Bao-Chun JiangYong-Jing Gao
Feb 26, 2021·Allergy·Angeliki DatsiJoerg Buddenkotte
Apr 4, 2021·Vaccines·Simone GarcovichGiampiero Girolomoni
Apr 29, 2021·Seminars in Hematology·John C Reneau, Ryan A Wilcox
May 1, 2021·Journal of Clinical Medicine·Masutaka Furue, Mihoko Furue
Apr 21, 2019·The Journal of Allergy and Clinical Immunology·Takashi Hashimoto, Gil Yosipovitch
Jun 14, 2021·Clinical and Molecular Allergy : CMA·Eleonora Di SalvoSebastiano Gangemi
Aug 3, 2021·Advances in Hematology·Maria AbreuMargarida Lima
Sep 15, 2021·Acta Dermato-venereologica·Ahmed A HawashGil Yosipovitch

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