Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Ingo J DielMF 4265 Study Group

Abstract

Bone metastases occur in most women with advanced breast cancer and can lead to considerable morbidity and a rapid deterioration in the patient's quality of life. It was the aim of the present study to assess changes in quality of life and bone pain due to intravenous (i.v.) ibandronate, a potent third-generation bisphosphonate. In a phase III randomised, double-blind, placebo-controlled trial in patients with bone metastases due to breast cancer, 466 women were randomised to receive placebo, 2 mg ibandronate or 6 mg ibandronate for up to 96 weeks. Treatment was administered i.v. at 3- or 4-weekly intervals. Clinical endpoints included the incidence of adverse events, quality of life (assessed using the European Organisation for the Research and Treatment of Cancer (EORTC) Quality of Life Scale - Core 30 questionnaire (QLQ-C30)), and bone pain (assessed on a 5-point scale from 0=none to 4=intolerable). Ibandronate was generally well tolerated. Compared with baseline measurements, the bone pain score was increased at the last assessment in both the placebo and 2 mg ibandronate groups, but was significantly reduced in the patients receiving 6 mg ibandronate (-0.28+/-1.11, P < 0.001). A significant improvement in quality of life w...Continue Reading

References

Oct 1, 1992·Anti-cancer Drugs·R L Theriault, G N Hortobagyi
Jun 15, 1996·The Journal of Clinical Investigation·G A Rodan, H A Fleisch
Aug 14, 1999·Journal of Internal Medicine·B KristensenH T Mouridsen
Jun 1, 2000·Breast Cancer Research and Treatment·E F SolomayerG Bastert
Feb 20, 2003·Journal of the National Cancer Institute·Pamela J GoodwinPatricia A Ganz
Sep 5, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-J BodyUNKNOWN MF 4265 Study Group

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Citations

Jan 26, 2007·Der Orthopäde·A A KurthI Diel
Feb 2, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jean-Jacques Body
Mar 30, 2007·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ingo J Diel
Apr 9, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Luis CostaAndrew Wardley
Aug 7, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Roger von MoosKathrin Zaugg
Feb 13, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ingo J DielRaoul Bergner
Apr 20, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J-J BodyB Bergström
Mar 13, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R von MoosM Pecherstorfer
Aug 13, 2008·Journal of the National Cancer Institute·Ollie MintonPatrick Stone
Jan 11, 2011·Journal of the National Cancer Institute·Julie LemieuxValérie Théberge
Jan 1, 2010·ClinicoEconomics and Outcomes Research : CEOR·Athanasios PallisNikos Maniadakis
Jan 1, 2008·Journal of Pain Research·Sukirtha TharmalingamEmily Sinclair
Feb 4, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Louis S MatzaDonald L Patrick
Feb 28, 2009·Women's Health·Martin Pecherstorfer
Apr 13, 2005·Clinical Therapeutics·Debu TripathyBengt Bergström
May 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Vassilios VassiliouDimitrios Kardamakis
Feb 7, 2016·Bone·Cecília J AlvesMeriem Lamghari
Dec 21, 2004·Expert Review of Anticancer Therapy·Axel Heidenreich, Carsten H Ohlmann
May 14, 2008·Expert Opinion on Pharmacotherapy·Vincenzo AdamoGiuseppe Tonini
Apr 9, 2009·Expert Opinion on Pharmacotherapy·James M Heun, Aminah Jatoi
Dec 7, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Raja S BobbaJonathan D Adachi
Mar 8, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·Vassilios Vassiliou
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Edward ChowUNKNOWN EORTC Quality of Life Group
Jul 18, 2008·Supportive Cancer Therapy·Allan Lipton
May 22, 2007·Hematology/oncology Clinics of North America·Rachel LaymanCatherine Van Poznak
Apr 3, 2007·Journal of Pain and Symptom Management·Julie Gralow, Debu Tripathy
Jun 26, 2009·European Journal of Cancer Care·P HerasA-P Georgopoulou
Aug 9, 2008·Australian Dental Journal·N U ZitzmannG Krastl
Jan 29, 2011·Acta Clinica Belgica·S De Waele, S Van Belle
Feb 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tara L AghalooSotirios Tetradis
Nov 7, 2006·International Journal of Radiation Oncology, Biology, Physics·Vassilios VassiliouDimitrios Kardamakis
Oct 19, 2004·Seminars in Oncology·Axel HeidenreichJean-Jacques Body

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