Improved quality of life is partly explained by fewer symptoms after treatment of fibroids with mifepristone.

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Changyong FengKevin Fiscella

Abstract

To examine mediators of mifepristone treatment on improvements in health-related quality of life (HRQOL) among women with symptomatic fibroids. The study sample included women with symptomatic uterine fibroids who were treated with 5mg or 2.5mg of mifepristone or placebo. Assessments of uterine size (ultrasound), pain (McGill pain questionnaire), bleeding (diary), anemia (gm/dL), and HRQOL measured using the uterine fibroid symptom quality of life scale were done at baseline, 3 months, and 6 months. The improvements in HRQOL that could be explained by changes in these clinical factors were assessed. The final sample included 62 women. Treatment with mifepristone was associated with significant improvement in HRQOL, which was explained in part by reduction in pain (28%, P<0.001) and bleeding (18%, P<0.001). Reduction in uterine volume was of marginal significance (P=0.05) and was associated with a decrease in HRQOL (7%). Much of the impact of treatment on HRQOL (61%) remained unexplained in this model. Improvements in HRQOL after treatment with mifepristone are partly explained by improvements in pain and bleeding, but not uterine size. However, most of the improvement in HRQOL is not explained by improvements in these clinical ...Continue Reading

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Citations

May 16, 2012·Journal of Assisted Reproduction and Genetics·Gary LevyWilliam H Catherino
Jul 27, 2011·Human Reproduction Update·Pasquapina CiarmelaMario Castellucci
Jul 1, 2014·Maturitas·Faustino R Pérez-LópezMargaret Rees
May 3, 2014·Expert Opinion on Pharmacotherapy·Giuseppe BenagianoIvo Brosens
Oct 8, 2013·Fertility and Sterility·Qi ShenXueqiong Zhu
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Mar 23, 2018·Obstetrics & Gynecology Science·Geum Seon SohnUNKNOWN Working Group of Society of Uterine Leiomyoma

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