Improved quantification for local regions of interest in preclinical PET imaging

Physics in Medicine and Biology
Jacobo Cal-GonzálezJosé M Udías

Abstract

In Positron Emission Tomography, there are several causes of quantitative inaccuracy, such as partial volume or spillover effects. The impact of these effects is greater when using radionuclides that have a large positron range, e.g. (68)Ga and (124)I, which have been increasingly used in the clinic. We have implemented and evaluated a local projection algorithm (LPA), originally evaluated for SPECT, to compensate for both partial-volume and spillover effects in PET. This method is based on the use of a high-resolution CT or MR image, co-registered with a PET image, which permits a high-resolution segmentation of a few tissues within a volume of interest (VOI) centered on a region within which tissue-activity values need to be estimated. The additional boundary information is used to obtain improved activity estimates for each tissue within the VOI, by solving a simple inversion problem. We implemented this algorithm for the preclinical Argus PET/CT scanner and assessed its performance using the radionuclides (18)F, (68)Ga and (124)I. We also evaluated and compared the results obtained when it was applied during the iterative reconstruction, as well as after the reconstruction as a postprocessing procedure. In addition, we stud...Continue Reading

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Citations

Sep 3, 2016·Medical Physics·Chung ChanChi Liu
Dec 6, 2019·The British Journal of Radiology·Jacek KwiecinskiDaniel S Berman
Feb 9, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jacobo Cal-GonzalezThomas Beyer
Jul 23, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ivo RauschJacobo Cal-González
Sep 12, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jakub Toczek, Laurent Riou

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