Improved radiocarbon analyses of modern human hair to determine the year-of-death by cross-flow nanofiltered amino acids: common contaminants, implications for isotopic analysis, and recommendations

Rapid Communications in Mass Spectrometry : RCM
Guaciara M SantosSteven Saverwyns

Abstract

In forensic investigation, radiocarbon ((14)C) measurements of human tissues (i.e., nails and hair) can help determine the year-of-death. However, the frequent use of cosmetics can bias hair (14)C results as well as stable isotope values. Evidence shows that hair exogenous impurities percolate beyond the cuticle layer, and therefore conventional pretreatments are ineffective in removing them. We conducted isotopic analysis ((14)C, δ(13)C, δ(15)N and C/N) of conventionally treated and cross-flow nanofiltered amino acid (CFNAA)-treated samples (scalp- and body-hair) from a single female subject using fingernails as a reference. The subject studied frequently applies a permanent dark-brown dye kit to her scalp-hair and uses other care products for daily cleansing. We also performed pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) analyses of CFNAA-treated scalp-hair to identify contaminant remnants that could possibly interfere with isotopic analyses. The conventionally treated scalp- and body-hair showed (14)C offsets of ~21‰ and ~9‰, respectively. These offsets confirm the contamination by petrochemicals in modern human hair. A single CFNAA extraction reduced those offsets by ~34%. No significant improvement was observe...Continue Reading

References

Jul 22, 1969·Journal of Chromatography·R E ExssG K Summer
Jan 5, 1995·Forensic Science International : Synergy·C Staub
Jan 5, 1995·Forensic Science International : Synergy·C M Selavka, F Rieders
Jan 1, 1994·Skin Pharmacology : the Official Journal of the Skin Pharmacology Society·T KealeyM P Philpott
Jan 17, 1997·Forensic Science International : Synergy·H Sachs
May 6, 1999·American Journal of Physical Anthropology·T C O'Connell, R E Hedges
Jun 23, 1999·Journal of Chromatography. a·W Meier-Augenstein
Mar 27, 2001·Cleveland Clinic Journal of Medicine·W F Bergfeld, F Mulinari-Brenner
Nov 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jonathan H Williams, Tamsin C O'Connell
Jun 1, 1961·The Anatomical Record·A D DIXON
Jan 30, 2007·The Journal of Physical Chemistry. B·Ken C HunterStacey D Wetmore
May 28, 2008·International Journal of Cosmetic Science·A R Mainkar, C I Jolly
Jul 14, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Klaus J PetzkeCornelia C Metges
Dec 29, 2010·International Journal of Trichology·Zoe D Draelos
Mar 19, 2011·Rapid Communications in Mass Spectrometry : RCM·Luciano O ValenzuelaJames R Ehleringer
May 3, 2011·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Camilla Friis BengtssonM Thomas P Gilbert
Sep 20, 2011·International Journal of Cosmetic Science·A O EvansR R Wickett
Nov 1, 2011·Forensic Science International : Synergy·Sebastian BroeckerFritz Pragst
Nov 18, 2011·Forensic Science International : Synergy·Gail A A CooperUNKNOWN Society of Hair Testing
Feb 19, 2013·BMC Biotechnology·Ana Lúcia Vazquez VillaAlane Beatriz Vermelho
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Kevin T UnoThure E Cerling

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Citations

Nov 7, 2019·Journal of Forensic Sciences·Eden Centaine Johnstone-Belford, Soren Blau

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