Improved Release of Celecoxib from High Drug Loading Amorphous Solid Dispersions Formulated with Polyacrylic Acid and Cellulose Derivatives

Molecular Pharmaceutics
Tian Xie, Lynne S Taylor

Abstract

Amorphous solid dispersions (ASDs) have been extensively exploited as a strategy for improving the dissolution performance of poorly water-soluble drugs. However, factors underpinning the observed dissolution profiles are not clearly understood, and the choice of polymeric carriers is largely empirical. In the current study, the dissolution performance of a high drug loading ASD containing the poorly water-soluble, anti-inflammatory agent, celecoxib, was optimized by using binary polymers combinations. Polyacrylic acid (PAA), a highly water-soluble polymer, was used to substantially increase the dissolution rate of the drug, while hydroxypropyl methyl cellulose (HPMC) or HPMC acetate succinate (HPMCAS) were added to stabilize the solid amorphous matrix against crystallization upon hydration, as well as to maintain supersaturation. Quantitative measurements of the impact of the polymers on the solution nucleation and growth rates of celecoxib revealed that, while the cellulose derivatives are effective nucleation inhibitors, it is more difficult to completely prevent crystal growth in solutions containing seed crystals, in particular at high supersaturations. Therefore, it is critical to prevent the formation of crystals in the ...Continue Reading

References

Sep 1, 1971·Journal of Pharmaceutical Sciences·W L Chiou, S Riegelman
May 1, 1969·Journal of Pharmaceutical Sciences·A P SimonelliW I Higuchi
Feb 13, 2001·International Journal of Pharmaceutics·S L RaghavanJ Hadgraft
Nov 1, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Garima ChawlaArvind K Bansal
Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mahaveer D Kurkuri, Tejraj M Aminabhavi
Nov 24, 2004·Pharmaceutical Research·Piyush GuptaArvind K Bansal
Aug 26, 2006·Pharmaceutical Research·Patrick J MarsacLynne S Taylor
Dec 7, 2007·Drug Discovery Today·Teófilo VasconcelosPaulo Costa
Oct 28, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Jessica AlbersPeter Kleinebudde
Apr 18, 2009·Journal of Pharmaceutical Sciences·Joachim BrouwersPatrick Augustijns
Aug 22, 2009·Journal of Pharmaceutical Sciences·Sharad B MurdandeRobin H Bogner
Sep 23, 2009·Pharmaceutical Research·Alfred C F RumondorLynne S Taylor
Feb 13, 2010·Pharmaceutical Research·David E AlonzoLynne S Taylor
May 25, 2011·Journal of Pharmaceutical Sciences·David E AlonzoLynne S Taylor
Nov 23, 2011·The AAPS Journal·Bruce J Aungst
Jul 24, 2012·International Journal of Pharmaceutics·Amrit PaudelGuy Van den Mooter
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Jan 3, 2014·Journal of Pharmaceutical Sciences·Shweta A RainaLynne S Taylor
May 16, 2014·Journal of Pharmaceutical Sciences·Joyann A MarksKevin J Edgar
May 17, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andrew V EwingSergei G Kazarian
Sep 22, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Caitlin J SchramStephen P Beaudoin

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Citations

Mar 26, 2016·Advanced Drug Delivery Reviews·Lynne S Taylor, Geoff G Z Zhang
Sep 4, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Peng ZhangMaria Strømme
Oct 8, 2016·Biomacromolecules·Laura I Mosquera-GiraldoLynne S Taylor
May 20, 2017·Pharmaceutical Research·Khadijah EduengChristel A S Bergström
Aug 11, 2017·ChemistryOpen·David LimónLluïsa Pérez-García
Jul 22, 2018·Drug Development and Industrial Pharmacy·Wenbao ZuoJianhong Yang
Nov 9, 2020·AAPS PharmSciTech·Athira R NairSwapnil J Dengale
Mar 11, 2020·International Journal of Pharmaceutics: X·Deanna M MudieDavid T Vodak
May 28, 2021·Molecular Pharmaceutics·Samarth D ThakoreArvind K Bansal

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