Improved results of cervical reoperation for medullary thyroid carcinoma

Annals of Surgery
J F MoleyM K Debenedetti

Abstract

The purpose of the study is to determine whether reoperation for medullary thyroid carcinoma (MTC), performed with low morbidity in carefully selected patients, consistently results in improvement as determined by lowering of stimulated calcitonin levels. Persistent or recurrent elevation of stimulated plasma calcitonin levels occurs in > 50% of patients after primary operation for MTC. Success of reoperation with clearance of metastatic cervical nodal disease has been hampered by failure to identify patients with distant metastases and by inadequate removal of involved nodal groups. Since 1992, the authors have evaluated 115 patients with recurrent or residual MTC. Fifty-three patients have not undergone operation because of extent of disease, previous extensive treatment, medical condition, or patient choice. Sixty-two patients underwent surgery. Ten patients had laparoscopic or open examination of the liver, the results of which showed liver metastases. Seven patients had palliative debulking of cervical tumor. In 45 patients without evidence of distant metastases, cervical operation was carried out with curative intent. Removal of central, upper mediastinal, and lateral nodes (levels II, III, IV, VI, and VII) was done. Seve...Continue Reading

References

Feb 1, 1979·The Surgical Clinics of North America·S A WellsR S Gray
Apr 1, 1972·American Journal of Surgery·H H MillerA H Tashjian
Jun 1, 1995·The Surgical Clinics of North America·J F Moley

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Citations

Jun 1, 2000·Cancer Control : Journal of the Moffitt Cancer Center·G W Randolph, D Maniar
Jun 12, 2002·Current Treatment Options in Oncology·E Kebebew, O H Clark
Aug 29, 2003·Current Treatment Options in Oncology·Jeffrey F Moley
Jun 22, 2005·Current Treatment Options in Oncology·Frank Jay Quayle, Jeffrey F Moley
Jul 29, 1998·Journal of Internal Medicine·J F MoleyS A Wells
May 28, 2009·Thyroid : Official Journal of the American Thyroid Association·UNKNOWN American Thyroid Association Guidelines Task ForceSamuel A Wells
Nov 24, 1999·Annals of Surgery·J B FlemingD B Evans
Dec 21, 2004·Journal of Internal Medicine·A MachensH Dralle
Apr 12, 2007·World Journal of Surgery·Y Nancy You, Samuel A Wells
Apr 12, 2007·World Journal of Surgery·Jeffrey F Moley, Elizabeth A Fialkowski
Jan 12, 2008·World Journal of Surgery·Elizabeth FialkowskiJeffrey Moley
Apr 12, 2011·World Journal of Surgery·Prateek Kumar MehrotraAshok Kumar Verma
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Theresia WeberMagnus von Knebel Doeberitz Mv
Dec 21, 2010·Seminars in Oncology·Susan C Pitt, Jeffrey F Moley
Jun 1, 2010·Otolaryngologic Clinics of North America·Alan P B Dackiw
Dec 2, 2008·Otolaryngologic Clinics of North America·Francis P Ruggiero, Fred G Fedok
Apr 1, 2008·Surgical Oncology Clinics of North America·Matthew L White, Gerard M Doherty
Aug 3, 2006·Surgical Oncology Clinics of North America·Y Nancy YouJeffrey F Moley
Nov 30, 2006·Journal of Surgical Oncology·Elizabeth A Fialkowski, Jeffrey F Moley
Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P SzavcsurO Esik
Oct 16, 2014·Annals of Surgical Oncology·Hans H G VerbeekJohn Th M Plukker
Sep 23, 2014·Annals of Surgical Oncology·Kathryn J RowlandJeffrey F Moley
Jun 8, 2007·The Journal of Chemical Physics·Rei Kurita, Hajime Tanaka
Apr 17, 2016·The Journal of Chemical Physics·S Bernini, D Leporini
Apr 14, 2007·The Journal of Chemical Physics·Jan WedekindDavid Reguera
Oct 24, 2007·The Journal of Chemical Physics·R A L ValléeK Binder
Aug 7, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E MiralliéJ F Henry
Dec 2, 2000·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·H Tanaka
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·G MonacoF Sette
Aug 31, 2002·Head & Neck·Carl N ValentineRichard A Prinz
Feb 19, 2005·Journal of Surgical Oncology·Frank J Quayle, Jeffrey F Moley
May 21, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A AttiliM Rovere
May 3, 2007·The Laryngoscope·Juan Manuel Fernandez VilaJean C Lifante

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