Improved risk assessment by screening sperm parameters

Toxicology Letters
S Plassmann, H Urwyler

Abstract

The question of whether a 4 or 9 week premating treatment period is more suitable in studies for effects on fertility and early embryonic development, and the extent to which the screening of sperm parameters may contribute to the detection of effects, has been under discussion since the ICH guideline changed in 1994/1995. This study presents a comparison between 4 and 9 weeks treatment with known male reproductive toxicants with regard to sperm motility, count, morphology, abnormal movements and testicular and epididymal histopathology. Mating outcome was examined after 4 weeks treatment. Three compounds with different targets and mechanisms of action were chosen: two testicular toxicants, Pyridoxine and Adriamycin and the epididymal toxicant, alpha-Chlorohydrine. Sperm motility was reduced in males treated with Pyridoxine (markedly) and alpha-Chlorohydrine (slightly) after 4 weeks treatment and in males treated with Adriamycin after 9 weeks treatment. With Pyridoxine and Adriamycin, sperm count was significantly increased after 4 weeks. Histopathological examination after 4 weeks showed characteristic changes leading to marked testicular tubular atrophy at 8/9 weeks, which was confirmed by a significantly reduced sperm count ...Continue Reading

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Jan 1, 1991·Adverse Drug Reactions and Toxicological Reviews·R BassJ Manson
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Jan 1, 1988·Reproductive Toxicology·J A WardI D Morris
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Aug 1, 1995·The Journal of Toxicological Sciences·S TsutsumiM Akaike

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Citations

May 22, 2002·Contraception·Grazia Petrelli, Alberto Mantovani
Mar 15, 2011·Reproductive Biology and Endocrinology : RB&E·Carla D B FernandezWilma D G Kempinas
Aug 3, 2012·Journal of Toxicology and Environmental Health. Part a·Thais Petrochelli BanzatoWilma De Grava Kempinas
Nov 26, 2008·Reproductive Toxicology·Mirja NurmioKirsi Jahnukainen
Sep 27, 2005·Contraception·Alberto Mantovani, Francesca Maranghi
Sep 8, 2007·International Journal of Andrology·Carla Dal Bianco FernandezWilma De Grava Kempinas
Mar 8, 2008·Molecular Reproduction and Development·Kazuyuki HiratsukaJunji Yamada
Jun 30, 2016·Reproductive Toxicology·Marciana SanabriaWilma De Grava Kempinas

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