Improved sample preparation of glyphosate and methylphosphonic acid by EPA method 6800A and time-of-flight mass spectrometry using novel solid-phase extraction

Journal of Mass Spectrometry : JMS
Rebecca WagnerH M Skip Kingston

Abstract

The employment of chemical weapons by rogue states and/or terrorist organizations is an ongoing concern in the United States. The quantitative analysis of nerve agents must be rapid and reliable for use in the private and public sectors. Current methods describe a tedious and time-consuming derivatization for gas chromatography-mass spectrometry and liquid chromatography in tandem with mass spectrometry. Two solid-phase extraction (SPE) techniques for the analysis of glyphosate and methylphosphonic acid are described with the utilization of isotopically enriched analytes for quantitation via atmospheric pressure chemical ionization-quadrupole time-of-flight mass spectrometry (APCI-Q-TOF-MS) that does not require derivatization. Solid-phase extraction-isotope dilution mass spectrometry (SPE-IDMS) involves pre-equilibration of a naturally occurring sample with an isotopically enriched standard. The second extraction method, i-Spike, involves loading an isotopically enriched standard onto the SPE column before the naturally occurring sample. The sample and the spike are then co-eluted from the column enabling precise and accurate quantitation via IDMS. The SPE methods in conjunction with IDMS eliminate concerns of incomplete eluti...Continue Reading

References

Aug 19, 2000·Journal of Chromatography. a·E Börjesson, L Torstensson
Mar 5, 2002·Journal of Chromatography. a·Zbigniew H KudzinJerzy Luczak
Jul 17, 2003·Journal of Chromatography. a·Zbigniew H KudzinJerzy Luczak
Jan 25, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·James RichesRobin M Black
Jan 18, 2006·Journal of the American Society for Mass Spectrometry·Wes E SteinerVincent M McHugh
Aug 29, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Frederic L CinerTimothy R Croley
Jun 19, 2007·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Tetsuya IshiwataKousaburo Ohashi
Oct 24, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Megumi MotojyukuSadaki Inokuchi

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Citations

Oct 11, 2015·Pest Management Science·William C KoskinenKathleen E Hall
May 22, 2016·Journal of Chromatography. a·Alberto Gomez-CaballeroRamón J Barrio
Mar 31, 2017·Environmental Science and Pollution Research International·Bérengère ClaudePhilippe Morin
Feb 29, 2020·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·João P F TiagoFlaviano O Silvério

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