Improved scoring system to assess adult donors for cadaver renal transplantation

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Scott L NybergM D Stegall

Abstract

We previously proposed a quantitative approach to assess donor organs for cadaver renal transplantation. To improve on our original scoring system, we studied 34 324 patients who received cadaver renal transplants from adult donors between 1994 and 1999 and were reported to the UNOS Scientific Renal Transplant Registry. A scoring system was developed from five donor variables (age, 0-25 points; history of hypertension, 0-4; creatinine clearance before procurement, 0-4; cause of death, 0-3; HLA mismatch, 0-3) that showed a significant correlation with renal function and long-term graft survival. Cadaver kidneys were stratified by cumulative donor score: grade A, 0-9 points; grade B, 10-19; grade C, 20-29; and grade D, 30-39. The influence of donor score on renal function and graft survival was most severe above 20 points, designated 'marginal' kidneys. In summary, a donor scoring system developed from a large population database was useful in predicting outcome after cadaver renal transplantation. The improved system provides a quantitative approach to evaluation of marginal kidneys and may improve allocation of these organs in cadaver renal transplantation.

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Mar 20, 1999·Transplantation Proceedings·G OpelzB Döhler
Nov 5, 1999·The New England Journal of Medicine·M A SchnitzlerD C Brennan
Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Akinlolu O OjoFriedrich K Port
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J Matas, F L Delmonico

❮ Previous
Next ❯

Citations

Mar 2, 2005·Journal of the American College of Surgeons·James A Schulak
Mar 12, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carine DietPhilippe Grimbert
Feb 16, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Motaz A ObeidatThomas F Mueller
Apr 14, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ronik S BhangooChirag R Parikh
Jul 25, 2006·Transplantation·Edwina S Baskin-BeyScott L Nyberg
May 7, 2011·Transplantation·Anja GallinatGeorgios C Sotiropoulos
Dec 20, 2011·Transplantation·Christopher J E WatsonJ Andrew Bradley
Feb 9, 2013·American Journal of Nephrology·Gaetano La MannaSergio Stefoni
Feb 18, 2010·European Journal of Medical Research·M HeuerJürgen W Treckmann
May 7, 2011·Critical Care : the Official Journal of the Critical Care Forum·Maria E HollmenKaija T Salmela
Dec 17, 2008·Journal of the American Society of Nephrology : JASN·Markus GiessingLutz Liefeldt
Jun 23, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Isaac E HallChirag R Parikh
Feb 9, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Faissal Abdulraheem ShaheenAbdulla Al Sayyari
Jan 29, 2011·Seminars in Immunopathology·Thomas F MuellerValeria Mas
Mar 25, 2014·Transplantation Proceedings·S-C WengD-C Tarng
Nov 28, 2012·Journal of Vascular and Interventional Radiology : JVIR·Boris NikolicWael A Saad
Nov 29, 2013·Kidney International·M Antonieta AzancotDaniel Seron
Jul 28, 2012·The Journal of Surgical Research·Georgios Tsoulfas
Feb 9, 2012·Transplantation Proceedings·J C JeongJ Yang
Nov 19, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eric S WeissAshish S Shah
Aug 31, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Bertram L KasiskeEric D Weinhandl
Oct 28, 2009·Transplantation Proceedings·P DomagalaA Chmura
Jul 11, 2009·Néphrologie & thérapeutique·Odette AbbadieBruno Hurault de Ligny
Aug 30, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Julio PascualJohn D Pirsch
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Edwina S Baskin-BeyScott L Nyberg
Jul 6, 2004·Clinical Transplantation·Scott L Nyberg
May 10, 2005·Clinical Transplantation·Edwina S Baskin-BeyScott L Nyberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Jesse D ScholdHerwig-Ulf Meier-Kriesche
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
D AnglicheauChristophe Legendre
© 2022 Meta ULC. All rights reserved