Improved Sleep Quality is Associated with Reductions in Depression and PTSD Arousal Symptoms and Increases in IGF-1 Concentrations

Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine
Heather L RuschJessica M Gill

Abstract

One-third of deployed military personnel will be diagnosed with insomnia, placing them at high risk for comorbid depression, posttraumatic stress disorder (PTSD), and medical conditions. The disruption of trophic factors has been implicated in these comorbid conditions, which can impede postdeployment recovery. This study determined if improved sleep quality is associated with (1) reductions in depression and posttraumatic symptoms, as well as enrichments in health-related quality of life (HRQOL), and (2) changes in plasma concentrations of brain derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1). Forty-four military personnel diagnosed with insomnia underwent clinical evaluations and blood draws at pretreatment and at posttreatment following cognitive behavioral therapy for insomnia and automatic positive airway pressure treatment. Participants were classified as sleep improved (n = 28) or sleep declined (n = 16) based on their change in pretreatment to posttreatment Pittsburgh Sleep Quality Index (PSQI) score. Both groups were compared on outcomes of depression, PTSD, HRQOL, BDNF, and IGF-1. Paired t-tests of the sleep improved group revealed significant declines in depression (p = 0.005) and posttrau...Continue Reading

Citations

Aug 26, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mounir ChennaouiDanielle Gomez-Merino
Nov 23, 2018·Medicina·Lucas Jurado-FasoliManuel J Castillo
Jan 5, 2018·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Bárbara C MonteiroSergio Machado
Jun 9, 2020·Frontiers in Psychiatry·Felipe Cesar de Almeida ClaudinoNeusa Sica da Rocha
Apr 18, 2020·BMC Psychiatry·Quinn M BiggsCarol S Fullerton
Dec 24, 2018·Annals of the New York Academy of Sciences·Heather L RuschJessica M Gill

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