Improved Solubility and Bioactivity of Camptothecin Family Antitumor Drugs with Supramolecular Encapsulation by Water-Soluble Pillar[6]arene

ACS Omega
Yamin LiuJiandong Ding

Abstract

Water-soluble pillar[6]arene (WP6) was used to solubilize camptothecin family antitumor drugs. In the presence of WP6, the solubility of camptothecin (CPT) and 10-hydroxycamptothecin (HCPT) was enhanced by 380 and 40 times, respectively. The solubility enhancement is proved to be the result of the host-guest encapsulation by WP6. WP6 has a low cytotoxicity against normal MC 3T3-E1 cells, whereas the bioactivity of CPT and HCPT is substantially improved as a result of the solubility enhancement.

References

Nov 1, 1986·Journal of Medicinal Chemistry·M C WaniM E Wall
Sep 11, 2007·International Journal of Pharmaceutics·Lin YuJian Dong Ding
Mar 25, 2008·Journal of the American Chemical Society·Tomoki OgoshiYoshiaki Nakamoto
Jan 30, 2010·Molecular Pharmaceutics·Vincent J Venditto, Eric E Simanek
Jun 15, 2010·The Journal of Organic Chemistry·Da MaLyle Isaacs
Nov 9, 2010·Chemical Communications : Chem Comm·Chunju LiXueshun Jia
Jul 23, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guangtao ChangJiandong Ding
Mar 2, 2012·Chemical Communications : Chem Comm·Tomoki OgoshiNoriyoshi Matsumi
Oct 6, 2012·Chemical Communications : Chem Comm·Xiao-Bo HuZhan-Ting Li
Feb 13, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Krishna GavvalaPartha Hazra
Sep 26, 2013·Journal of the American Chemical Society·Chenfeng KeJ Fraser Stoddart
Jul 2, 2015·Nature Communications·Sheng-Hua LiYu Liu
Jan 9, 2016·Journal of the American Chemical Society·Roymon JosephYoram Cohen
Apr 14, 2016·Organic & Biomolecular Chemistry·L S YakimovaI I Stoikov
Oct 26, 2016·Journal of Pharmaceutical Sciences·Nial J WheateDeborah J Marsh
Jul 12, 2017·Annals of the New York Academy of Sciences·Kit Ieng KuokRuibing Wang

❮ Previous
Next ❯

Citations

Nov 18, 2018·Chemical Communications : Chem Comm·Weiwei FengZhichao Pei
Feb 2, 2021·Chemical Society Reviews·Jiong ZhouFeihe Huang
Jun 28, 2021·European Journal of Medicinal Chemistry·Noura KhaiwaTaleb H Al-Tel

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.