Improved spatial characterization of the epileptic brain by focusing on nonlinearity

Epilepsy Research
Ralph G AndrzejakKlaus Lehnertz

Abstract

An advanced characterization of the complicated dynamical system brain is one of science's biggest challenges. Nonlinear time series analysis allows characterizing nonlinear dynamical systems in which low-dimensional nonlinearity gives rise to complex and irregular behavior. While several studies indicate that nonlinear methods can extract valuable information from neuronal dynamics, others doubt their necessity and conjecture that the same information can be obtained using classical linear techniques. To address this issue, we compared these two concepts, but included furthermore a combination of nonlinear measures with surrogates, an approach that has been designed to specifically focus on nonlinearity. As a benchmark we used the discriminative power to detect the seizure-generating hemisphere in medically intractable mesial temporal lobe epilepsy. We analyzed intracranial electroencephalographic recordings from the seizure-free interval of 29 patients. While the performance of both linear and nonlinear measures was weak, if not insignificant, a very high performance was obtained by the use of surrogate-corrected measures. Focusing on nonlinearity by using a combination of nonlinear measures with surrogates appears as the key...Continue Reading

References

Sep 1, 1992·The International Journal of Neuroscience·M G MarcianiG Bernardi
Jun 1, 1990·Electroencephalography and Clinical Neurophysiology·D Panet-Raymond, J Gotman
Nov 1, 1991·Electroencephalography and Clinical Neurophysiology·J P PijnF H Lopes da Silva
Feb 1, 1988·Electroencephalography and Clinical Neurophysiology·M R Nuwer
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A Babloyantz, A Destexhe
Sep 1, 1970·Electroencephalography and Clinical Neurophysiology·B Hjorth
Aug 1, 1995·Electroencephalography and Clinical Neurophysiology·K Lehnertz, C E Elger
May 1, 1996·Electroencephalography and Clinical Neurophysiology·J FellC Schäffner
Feb 1, 1997·Electroencephalography and Clinical Neurophysiology·M C CasdagliJ C Sackellares
Jul 1, 1997·Brain Topography·J P PijnF H Lopes da Silva
Apr 21, 1998·Seizure : the Journal of the British Epilepsy Association·M E DrakeS A Newell
Sep 1, 1986·Physical Review A: General Physics·J Theiler
Jul 15, 1987·Physical Review A: General Physics·F Kaspar, H G Schuster
Jan 27, 1992·Physical Review Letters·D T Kaplan, L Glass
Jul 22, 1996·Physical Review Letters·T Schreiber, A Schmitz
Feb 1, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Y ShenP F Meier
Mar 4, 2003·Nature Medicine·Patrick E McSharryLionel Tarassenko
Mar 15, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ralph G AndrzejakKlaus Lehnertz
Mar 15, 2003·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Florian MormannKlaus Lehnertz
Nov 18, 2003·Journal of Computational Neuroscience·Dingzhou LiRobert Savit
Feb 3, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ralph G AndrzejakThomas Kreuz
Feb 22, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Florian MormannKlaus Lehnertz
Oct 29, 2005·Journal of Neuroscience Methods·Andy MüllerKlaus Lehnertz

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Citations

Aug 12, 2009·Journal of Biological Physics·Klaus Lehnertz
Jul 16, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ptolemaios G SarrigiannisMarios Hadjivassiliou
Oct 23, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Roberto HorneroCarlos Gómez
Jul 12, 2007·Journal of Integrative Neuroscience·A KotiniP Prassopoulos
Dec 28, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Guillermo J OrtegaJesús Pastor
Jan 5, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marie-Therese HorstmannKlaus Lehnertz
Mar 13, 2009·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Giovanni Aschero, Paolo Gizdulich
May 20, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gaoxiang OuyangDouglas A Richards
Apr 9, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yingjie LiYisheng Zhu
May 20, 2015·International Journal of Neural Systems·Evelien E GeertsemaStiliyan N Kalitzin
May 30, 2015·International Journal of Neural Systems·Elisa BellistriVadym Gnatkovsky
Jun 2, 2009·Journal of Neuroscience Methods·Klaus LehnertzTobias Wagner
Jan 1, 2008·Chaos·Eshel Ben-JacobVernon L Towle
Jun 24, 2010·Journal of Neural Engineering·G E PolychronakiK S Nikita
May 16, 2007·Physical Review Letters·Jens Prusseit, Klaus Lehnertz
Jul 30, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Christian RummelKaspar Schindler
Mar 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Narayan Puthanmadam Subramaniyam, Jari Hyttinen
Jul 14, 2018·Neurology Research International·Jisu Elsa JacobK P Divya
May 24, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·R G AndrzejakF Mormann
Feb 7, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Stephan Bialonski, Klaus Lehnertz
Jun 13, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Gaoxiang OuyangDouglas A Richards
Oct 15, 2014·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Daniel NaroRalph G Andrzejak
Dec 12, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ralph G AndrzejakChristian Rummel

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