Improved spatial recognition memory in mice lacking adenosine A2A receptors

Experimental Neurology
Jian Hong WangMaarten van den Buuse

Abstract

Adenosine receptors play an important role in learning and memory as their antagonists have been found to facilitate learning and memory in various tasks in rodents. However, few studies have examined the effect of adenosine A2A receptor deficiency on cognition. In the present study, we therefore used the Y-maze, a simple two-trial recognition test to measure spatial recognition memory in mice lacking adenosine A2A receptors. The results showed that adenosine A2A receptor knockout mice had a higher percentage of novel arm visits as first choice than wild-type CD1 mice. Moreover, these mice showed longer duration of visits in the novel arm when compared with controls, suggesting that the lack of adenosine A2A receptors improved spatial recognition memory. On the other hand, mice lacking the adenosine A2A receptors had low scores in the number of arm visits, suggesting that they were hypoactive. In conclusion, these data suggest the involvement of adenosine receptors in modulating spatial recognition memory in mice, consistent with earlier findings using adenosine receptor antagonists.

References

Sep 1, 1994·Neuroscience·A de Mendonça, J A Ribeiro
Sep 1, 1994·Behavioral and Neural Biology·H J NormileR A Barraco
Jul 1, 1996·British Journal of Pharmacology·A K DixonT C Freeman
Apr 1, 1997·Psychopharmacology·C M FraserT W Stone
Mar 14, 2002·European Journal of Pharmacology·Grace S PereiraCarla D Bonan
May 25, 2002·Medical Hypotheses·R Machado-VieiraF Kapczinski
Nov 9, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M E M AngelucciC Da Cunha
Aug 6, 2003·Behavioural Brain Research·Jian Hong WangMaarten van den Buuse
Apr 12, 2005·Neurobiology of Learning and Memory·Grace Schenatto PereiraIván Izquierdo

❮ Previous
Next ❯

Citations

May 20, 2015·FEBS Letters·Yunhong Huang, Amantha Thathiah
Dec 10, 2014·Neurobiology of Learning and Memory·Josiane Woutheres BortolottoCarla Denise Bonan
Dec 9, 2008·Behavioural Brain Research·Olivia DeanMaarten van den Buuse
Jan 23, 2015·Addiction Biology·Rose ChesworthAndrew J Lawrence
May 6, 2015·British Journal of Pharmacology·N PagnussatL O Porciúncula
Mar 15, 2006·Expert Review of Neurotherapeutics·Marcelo E Bigal, Richard B Lipton
Jan 21, 2011·Nature Reviews. Neuroscience·Amantha Thathiah, Bart De Strooper
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Sep 7, 2018·Frontiers in Cellular Neuroscience·Md Ezazul HaqueDong-Kug Choi
Sep 29, 2019·Journal of Caffeine and Adenosine Research·Mariana Temido-FerreiraLuísa V Lopes
Dec 18, 2020·Biochemical Pharmacology·Cátia R LopesPaula M Canas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.