Improved statistical analysis of moclobemide dose effects on panic disorder treatment.

European Archives of Psychiatry and Clinical Neuroscience
Donald C RossE H Uhlenhuth

Abstract

Clinical trials with several measurement occasions are frequently analyzed using only the last available observation as the dependent variable [last observation carried forward (LOCF)]. This ignores intermediate observations. We reanalyze, with complete data methods, a clinical trial previously reported using LOCF, comparing placebo and five dosage levels of moclobemide in the treatment of outpatients with panic disorder to illustrate the superiority of methods using repeated observations. We initially analyzed unprovoked and situational, major and minor attacks as the four dependent variables, by repeated measures maximum likelihood methods. The model included parameters for linear and curvilinear time trends and regression of measures during treatment on baseline measures. Significance tests using this method take into account the structure of the error covariance matrix. This makes the sphericity assumption irrelevant. Missingness is assumed to be unrelated to eventual outcome and the residuals are assumed to have a multivariate normal distribution. No differential treatment effects for limited attacks were found. Since similar results were obtained for both types of major attack, data for the two types of major attack were ...Continue Reading

References

Sep 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·M VersianiR Amrein
Jan 1, 1988·Journal of Psychiatric Research·P Tyrer, C Shawcross
Jan 1, 1980·Archives of General Psychiatry·D V SheehanG Jacobsen
May 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M E ThaseA J Rush
Jan 1, 1995·Acta Psychiatrica Scandinavica. Supplementum·R G PriestJ Steinert
May 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·D F Klein, D C Ross
Aug 1, 1997·Journal of Clinical Psychopharmacology·R NoyesE H Uhlenhuth
Apr 16, 1998·The British Journal of Psychiatry : the Journal of Mental Science·F R SchneierM R Liebowitz
Mar 4, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F Lotufo-NetoM E Thase
Aug 17, 1999·The British Journal of Psychiatry : the Journal of Mental Science·B LoerchO Benkert
May 15, 2002·Journal of Clinical Psychopharmacology·E H UhlenhuthWilliam Matuzas

❮ Previous
Next ❯

Citations

Jul 8, 2011·The International Journal of Neuropsychopharmacology·Neeltje M BatelaanDan J Stein
Sep 27, 2018·Expert Opinion on Pharmacotherapy·Marco Mula

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.