Improved survival in granulomatosis with polyangiitis: A general population-based study

Seminars in Arthritis and Rheumatism
Zachary S WallaceHyon K Choi

Abstract

Granulomatosis with polyangiitis (GPA) is associated with an increased risk of mortality; however, recent mortality trends in GPA are unknown. We evaluated this issue in a general population context. Using data collected between 1992 and 2013 by The Health Improvement Network in the United Kingdom, we identified individuals diagnosed as incident cases of GPA and up to 10 non-GPA controls matched on sex, age, year of birth, and year of GPA diagnosis. The cohort was divided into two based on the year of diagnosis (i.e., 1992-2002 and 2003-2013) to evaluate changes in mortality. We calculated hazard ratios for death using a Cox-proportional hazards model and the rate differences using an additive hazard model, while adjusting for potential confounders. We identified 465 cases of GPA (mean age: 60 years, 52% male). The early cohort (1992-2002) GPA patients had considerably higher mortality rates than the late cohort (2003-2013) (i.e., 72.0 vs. 35.7 cases per 1000 person-years), as compared with a moderate improvement in the comparison cohorts between the two periods (19.8 vs. 17.0 cases per 1000 person-years). The corresponding absolute mortality rate difference was 52.2 (95% CI: 25.1-79.2) cases and 18.7 (95% CI: 8.3-29.1) cases p...Continue Reading

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Citations

Feb 18, 2016·Rheumatology International·Durga Prasanna Misra, Sajjan N Shenoy
Aug 26, 2016·Molecular and Cellular Probes·Manfred RelleAndreas Schwarting
Feb 18, 2018·Histopathology·Silke R BrixThorsten Wiech
Dec 6, 2017·Zeitschrift für Rheumatologie·Jan Henrik SchirmerFrank Moosig
May 5, 2017·Annals of the Rheumatic Diseases·Ju Ann TanJ Antonio Avina-Zubieta
Jan 5, 2018·BMJ Case Reports·David Owen ReesDavid Andrew Glover
Aug 16, 2019·Expert Review of Clinical Immunology·Christian Pagnoux, Arielle Mendel
Oct 8, 2019·Annals of Internal Medicine·Alexander W SteinbergEvans R Fernández Pérez
Mar 13, 2020·Scandinavian Journal of Rheumatology·S B KrintelM Faurschou
Nov 1, 2017·International Journal of Legal Medicine·Birthe HeitkötterDaniel Wittschieber
Mar 20, 2020·BMJ : British Medical Journal·Zachary S Wallace, Eli M Miloslavsky
Apr 20, 2019·International Journal of Environmental Research and Public Health·Germán Sánchez-DíazVerónica Alonso-Ferreira
Dec 24, 2019·Frontiers in Immunology·Zachary S Wallace, John H Stone
Sep 1, 2018·International Journal of Rheumatic Diseases·Durga P MisraAman Sharma
Dec 30, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ulrich SpecksFernando C Fervenza
Sep 19, 2017·Seminars in Arthritis and Rheumatism·Carolyn T ThorpeSusan L Hogan
Jul 10, 2021·Case Reports in Rheumatology·Rafael FigueiredoCarla Zilhão
Nov 16, 2021·Laryngo- rhino- otologie·Kim Vanessa Steinke, Hans-Jürgen Welkoborsky
Nov 6, 2021·Current Opinion in Rheumatology·Helena CrawshawJoanna C Robson

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