Improved survival with vemurafenib in melanoma with BRAF V600E mutation

The New England Journal of Medicine
Paul B ChapmanBRIM-3 Study Group

Abstract

Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032) have shown response rates of more than 50% in patients with metastatic melanoma with the BRAF V600E mutation. We conducted a phase 3 randomized clinical trial comparing vemurafenib with dacarbazine in 675 patients with previously untreated, metastatic melanoma with the BRAF V600E mutation. Patients were randomly assigned to receive either vemurafenib (960 mg orally twice daily) or dacarbazine (1000 mg per square meter of body-surface area intravenously every 3 weeks). Coprimary end points were rates of overall and progression-free survival. Secondary end points included the response rate, response duration, and safety. A final analysis was planned after 196 deaths and an interim analysis after 98 deaths. At 6 months, overall survival was 84% (95% confidence interval [CI], 78 to 89) in the vemurafenib group and 64% (95% CI, 56 to 73) in the dacarbazine group. In the interim analysis for overall survival and final analysis for progression-free survival, vemurafenib was associated with a relative reduction of 63% in the risk of death and of 74% in the risk of either death or disease progression, as compared with dacarbazine (P<0.001 for both compariso...Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P B ChapmanJohn M Kirkwood
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M R MiddletonN Thatcher
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M F AvrilY Menu
Nov 18, 2005·The New England Journal of Medicine·John A CurtinBoris C Bastian
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agop Y BedikianOblimersen Melanoma Study Group
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·James TsaiGideon Bollag
Aug 25, 2009·Journal of the American Academy of Dermatology·Eun Ji KwonChristine Jaworsky
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Jul 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eric W JosephNeal Rosen
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Nov 26, 2010·Nature·Cory M JohannessenLevi A Garraway
Feb 24, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G V LongRichard F Kefford
Mar 19, 2011·International Journal of Dermatology·Victoria L WilliamsDavid J Stewart
Feb 13, 2013·Clinical and Experimental Dermatology·G W M Millington

Citations

Aug 25, 2011·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Christian Hafner
Nov 2, 2012·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B M RudolphStephan Grabbe
Dec 8, 2011·Cancer Immunology, Immunotherapy : CII·Rui-Ru JiVafa Shahabi
Aug 28, 2013·Cancer Immunology, Immunotherapy : CII·Fredrik B ThorénÖrjan Strannegård
Feb 28, 2013·Cancer Chemotherapy and Pharmacology·Carolyn D Britten
Jun 14, 2012·Der Pathologe·M DietelR Stadler
Sep 13, 2012·Der Pathologe·J RüschoffP Middel
Apr 24, 2013·Acta Neuropathologica·Sonika DahiyaJeffrey R Leonard
Feb 22, 2012·Archives of Dermatological Research·Francesco Spagnolo, Paola Queirolo
Oct 12, 2012·Amino Acids·Nadine TandlerJens Pietzsch
Sep 13, 2011·Apoptosis : an International Journal on Programmed Cell Death·Vladimir N Ivanov, Tom K Hei
Jun 12, 2012·Cancer Metastasis Reviews·Aaron K MobleyMenashe Bar-Eli
Apr 16, 2013·Cancer Metastasis Reviews·Yabin ChengGang Li
Jun 5, 2012·Clinical & Experimental Metastasis·Keith T Flaherty
Aug 7, 2012·Investigational New Drugs·Patrick A OttJedd D Wolchok
Jan 15, 2013·Investigational New Drugs·Andrew PoklepovicJohn D Roberts
Aug 7, 2012·Journal of Mammary Gland Biology and Neoplasia·Justin Cidado, Ben Ho Park
Aug 23, 2011·Targeted Oncology·Jean-François Morère
Feb 22, 2012·Targeted Oncology·Junjie LiYicheng Ni
May 7, 2013·Targeted Oncology·Hans PrenenEric Van Cutsem
Jun 30, 2012·Current Treatment Options in Oncology·Brendan D Curti, Walter J Urba
Feb 20, 2013·Current Treatment Options in Oncology·Douglas B Johnson, Jeffrey A Sosman
Mar 19, 2013·Current Treatment Options in Oncology·Sarah NicholasMichael Lim
Jul 31, 2013·Current Hematologic Malignancy Reports·Robert J Kreitman
Jun 5, 2012·Current Oncology Reports·Michael A PostowRichard D Carvajal
Dec 12, 2012·Current Oncology Reports·Emma B Holliday, Erik P Sulman
Mar 7, 2013·Current Oncology Reports·Viswanath Reddy BelumMario E Lacouture
Jun 19, 2013·Current Oncology Reports·Shirish M Gadgeel
Sep 6, 2013·Current Oncology Reports·Aaron S Mansfield, Svetomir N Markovic
Aug 21, 2013·Current Oncology Reports·Vikram C GorantlaHussein A Tawbi
Aug 27, 2013·Current Oncology Reports·April K S Salama, Kevin Kim
Aug 13, 2013·Current Oncology Reports·David B PageJedd D Wolchok
May 4, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E EspinosaGrupo Español de Melanoma (GEM)
Nov 15, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G ArgilésJosep Tabernero
Apr 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Michael J Duffy
Jan 19, 2013·American Journal of Clinical Dermatology·Gillian M Keating, Katherine A Lyseng-Williamson
Mar 22, 2013·American Journal of Clinical Dermatology·Dragoslav ZikichMichal J Besser
May 17, 2013·American Journal of Clinical Dermatology·Marta BatusHoward L Kaufman
Feb 26, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Giuseppe AprileFrancesco Giuliani
May 8, 2013·Drugs·Charlotte LemechHendrik-Tobias Arkenau
Jul 3, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·A DucassouV Sibaud
Sep 3, 2013·Journal of Dermatological Science·Abdlsattar ZebaryJohan Hansson
Nov 12, 2013·Trends in Pharmacological Sciences·Lucio TentoriGrazia Graziani
Feb 19, 2013·The Lancet Oncology·Geoffrey T Gibney, Jeffrey Weber
Jul 3, 2013·The Lancet Oncology·Geoffrey T Gibney, Vernon K Sondak
Feb 11, 2014·The Lancet Oncology·Howard L Kaufman
Oct 13, 2012·Expert Reviews in Molecular Medicine·Sarah Belden, Keith T Flaherty
Apr 28, 2012·Journal of Medicinal Chemistry·Jie QinRonen Marmorstein
Jul 20, 2012·Journal of Medicinal Chemistry·Xiaolun Wang, Joseph Kim
Nov 10, 2011·Molecular Pharmaceutics·Edward H FlachAlexander R A Anderson
Aug 4, 2012·Cell Death and Differentiation·Yongping Shao, Andrew E Aplin
May 17, 2013·Journal of Human Genetics·Daniel L Hertz, Howard L McLeod
Apr 6, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alon D AltmanMartin Köbel
Aug 9, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Evanthia GalanisK Kendra
May 15, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chuanliang CuiJun Guo
May 25, 2012·Nature·Michael F BergerLevi A Garraway
Jul 12, 2012·Nature Biotechnology·Bissan Al-LazikaniPaul Workman
Jul 31, 2012·Nature Genetics·Michael KrauthammerRuth Halaban
Sep 28, 2013·Nature Genetics·Cancer Genome Atlas Research NetworkJoshua M Stuart
Feb 14, 2012·Nature Medicine·Doron LipsonPhilip J Stephens
Jul 24, 2012·Nature Medicine·Agnieszka GembarskaJean-Christophe Marine
Nov 10, 2013·Nature Medicine·Liling WanYibin Kang
Nov 10, 2013·Nature Medicine·Piro LitoDavid B Solit
Apr 6, 2013·Nature Medicine·Yevgeniy Grigoryev
Apr 6, 2012·Nature Reviews. Cancer·Keith T FlahertyDavid E Fisher
Mar 23, 2012·Nature Reviews. Cancer·Matthew Vanneman, Glenn Dranoff
Jun 8, 2012·Nature Reviews. Cancer·Christoph Bock, Thomas Lengauer
Mar 29, 2013·Nature Reviews. Cancer·Michael HölzelThomas Tüting
Aug 3, 2011·Nature Reviews. Clinical Oncology·Ignacio Garrido-LagunaRazelle Kurzrock
Aug 3, 2011·Nature Reviews. Clinical Oncology·Steven A Rosenberg
Jul 27, 2011·Nature Reviews. Clinical Oncology·Vernon K Sondak, Lawrence E Flaherty
Nov 16, 2011·Nature Reviews. Clinical Oncology·Miriam MartiniAlberto Bardelli
Nov 4, 2011·Nature Reviews. Clinical Oncology·Vincent T DeVita
Dec 7, 2011·Nature Reviews. Clinical Oncology·Manish R Sharma, Richard L Schilsky
Dec 21, 2011·Nature Reviews. Clinical Oncology·Dorothy M K Keefe, Emma H Bateman
Jan 11, 2012·Nature Reviews. Clinical Oncology·Alexander Eggermont, C Robert
Jul 25, 2012·Nature Reviews. Clinical Oncology·Kara N Maxwell, Susan M Domchek
Aug 2, 2012·Nature Reviews. Clinical Oncology·Funda Meric-Bernstam, Gordon B Mills
Aug 15, 2012·Nature Reviews. Clinical Oncology·Hussein A Tawbi, John M Kirkwood
Feb 22, 2012·Nature Reviews. Clinical Oncology·Bertil Jonsson, J Bergh
Sep 12, 2012·Nature Reviews. Clinical Oncology·Anas Younes, Donald A Berry
Sep 12, 2012·Nature Reviews. Clinical Oncology·Eric A CollissonJoe W Gray
Sep 12, 2012·Nature Reviews. Clinical Oncology·Javier Munoz, Razelle Kurzrock
Nov 28, 2012·Nature Reviews. Clinical Oncology·Shota TanakaJorg Dietrich
Dec 5, 2012·Nature Reviews. Clinical Oncology·Keiran S M Smalley, Vernon K Sondak
Mar 1, 2012·Nature Reviews. Clinical Oncology·Eric H Rubin, D Gary Gilliland
Jan 30, 2013·Nature Reviews. Clinical Oncology·Sook Ryun ParkShivaani Kummar
Jul 11, 2012·Nature Reviews. Clinical Oncology·Frédérique NowakFabien Calvo
Apr 5, 2012·Nature Reviews. Clinical Oncology·Jordi RodonJosep Tabernero
May 16, 2012·Nature Reviews. Clinical Oncology·Erica L Carpenter, Yael P Mossé
Feb 13, 2013·Nature Reviews. Clinical Oncology·Jordi RodonJosep Tabernero
May 29, 2013·Nature Reviews. Clinical Oncology·Geoffrey T GibneyKeiran S M Smalley
Aug 2, 2011·Nature Reviews. Drug Discovery·W Joost LesterhuisCornelis J A Punt
Nov 1, 2011·Nature Reviews. Drug Discovery·Keith T FlahertyPeter Kirkpatrick
Feb 11, 2012·Nature Reviews. Drug Discovery·Gary J Kelloff, Caroline C Sigman
Mar 2, 2012·Nature Reviews. Drug Discovery·Jack W ScannellBrian Warrington
Sep 25, 2012·Nature Reviews. Drug Discovery·Rosemary J Akhurst, Akiko Hata
Oct 13, 2012·Nature Reviews. Drug Discovery·Gideon BollagPeter Hirth
Mar 2, 2013·Nature Reviews. Drug Discovery·Douglas W McMillinConstantine S Mitsiades
Jan 1, 2013·Nature Reviews. Drug Discovery·Mishal N PatelBissan Al-Lazikani
Nov 14, 2012·Nature Reviews. Gastroenterology & Hepatology·Augusto VillanuevaJosep M Llovet
Sep 24, 2011·Nature Reviews. Molecular Cell Biology·Asifa AkhtarMarino Zerial
Feb 19, 2013·Oncogene·L N Kwong, Michael A Davies
Jul 5, 2012·The Pharmacogenomics Journal·A SavonarolaF Silvestris
Dec 23, 2011·The New England Journal of Medicine·Nicole M RochetSvetomir N Markovic
Feb 3, 2012·The New England Journal of Medicine·Reinhard DummerSimone M Goldinger
Mar 2, 2012·The New England Journal of Medicine·James J HardingPaul B Chapman
Jul 12, 2013·The New England Journal of Medicine·Ryan J SullivanAdriano Piris
Jun 7, 2011·The New England Journal of Medicine·Marc S Ernstoff
Jun 6, 2012·The New England Journal of Medicine·Edward A Sausville
Jan 20, 2012·The New England Journal of Medicine·Fei SuRichard Marais
Feb 24, 2012·The New England Journal of Medicine·Jeffrey A SosmanAntoni Ribas
Jun 6, 2012·The New England Journal of Medicine·Keith T FlahertyMETRIC Study Group
Nov 9, 2012·The New England Journal of Medicine·Margaret K CallahanPaul B Chapman
Oct 2, 2012·The New England Journal of Medicine·Keith T FlahertyJeffrey Weber
Jun 4, 2013·The New England Journal of Medicine·Jedd D WolchokMario Sznol
Dec 23, 2011·The New England Journal of Medicine·Robert Schwartz
Jun 1, 2012·The New England Journal of Medicine·Vincent T DeVita, Steven A Rosenberg
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Alessia BottosAlberto Bardelli
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhi-ming HuangMaria L Wei
Apr 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·David De SemirMohammed Kashani-Sabet
Mar 1, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rizwan HaqDavid E Fisher
Oct 19, 2012·The Journal of Biological Chemistry·Fred M KaplanAndrew E Aplin
Jul 19, 2012·Cancer Biotherapy & Radiopharmaceuticals·Robert O DillmanStephanie E McClure
Apr 12, 2013·Genetic Testing and Molecular Biomarkers·Yao-Shan Fan
Jul 17, 2012·Journal of Palliative Medicine·Thomas I Peng SohAlvin Seng Cheong Wong
Mar 16, 2013·Thyroid : Official Journal of the American Thyroid Association·Kevin KimSteven I Sherman
Nov 11, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L V SequistDora Dias-Santagata
Dec 28, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F MurphyM R Middleton
Aug 29, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Michele Maio
Aug 29, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Jedd D Wolchok
Oct 5, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P L MatteiA B Kimball
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Reinhard DummerSimone M Goldinger
Nov 23, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Hussein A TawbiJohn M Kirkwood
Feb 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L BoussemartC Robert
Jun 5, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G DanieleM Pirisi
Apr 12, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H HenaryRazelle Kurzrock
Apr 25, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P NathanPaul Lorigan
Dec 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Janet Dancey
May 4, 2013·Carcinogenesis·Jodi A McKenzieDouglas Grossman
Sep 22, 2012·Journal of the National Cancer Institute·Ahmad JaliliStephan N Wagner
Dec 20, 2012·Journal of the National Cancer Institute·Michael A Davies, Scott Kopetz
Mar 29, 2013·Journal of the National Cancer Institute·Christy C OngKlaus P Hoeflich
Mar 29, 2013·Journal of the National Cancer Institute·Keiran S M Smalley, Jeffrey Weber
Apr 12, 2012·Neuro-oncology·Craig HorbinskiIan F Pollack
Aug 26, 2011·The American Journal of Nursing·David Carter
Oct 13, 2012·Anti-cancer Drugs·Nicole A DoudicanSeth J Orlow
Feb 10, 2012·Current Opinion in Oncology·Reinhard Dummer, Keith T Flaherty
Feb 22, 2012·Current Opinion in Oncology·Jaap Verweij
Mar 14, 2012·Current Opinion in Oncology·Ahmad AwadaPhilippe G Aftimos
Jul 24, 2012·Current Opinion in Oncology·Riccardo SoffiettiRoberta Rudà
Jan 10, 2013·Current Opinion in Oncology·Michele MaioAlexander Eggermont
Jan 10, 2013·Current Opinion in Oncology·Lu Si, Jun Guo
Jan 22, 2013·Current Opinion in Oncology·Klaus G GriewankAnnette Paschen
Mar 16, 2013·Current Opinion in Oncology·Ahmad Awada, Philippe G Aftimos
Dec 2, 2011·Journal of Immunotherapy·Richard W JosephMichael A Davies
Jun 28, 2012·Journal of Immunotherapy·Gregory S VosganianLinda A Sherman
Oct 24, 2012·Journal of Immunotherapy·Travis B KidnerMark Faries
Mar 8, 2012·Melanoma Research·Vito W RebeccaKeiran S M Smalley
Sep 25, 2012·The American Journal of Dermatopathology·Mai P Hoang, Daniela Kroshinsky
Jul 10, 2012·The American Journal of Dermatopathology·Nathan T HarveyBenjamin A Wood
May 30, 2013·The American Journal of Dermatopathology·Katherine E BrickMargot S Peters
Dec 24, 2011·Current Opinion in Obstetrics & Gynecology·Anne O Rodriguez
May 2, 2012·Journal of Pediatric Hematology/oncology·Michelle NeierFariba Navid
Oct 13, 2012·Advances in Anatomic Pathology·Oliver G McDonaldRalph H Hruban
Sep 26, 2013·The American Journal of Surgical Pathology·Richard A ScolyerInternational Collaboration on Cancer Reporting
Dec 14, 2011·The Cancer Journal·David A FenstermacherWilliam S Dalton
Dec 14, 2011·The Cancer Journal·Keith T Flaherty
Mar 29, 2012·The Cancer Journal·Michael A Postow, Richard D Carvajal
Mar 29, 2012·The Cancer Journal·M S CarlinoG V Long
Mar 29, 2012·The Cancer Journal·Ragini R KudchadkarKeiran S M Smalley
Mar 29, 2012·The Cancer Journal·Fergal C Kelleher, Grant A McArthur
Mar 29, 2012·The Cancer Journal·Anna LeungDonald L Morton
Mar 29, 2012·The Cancer Journal·Scott E Woodman
Mar 29, 2012·The Cancer Journal·Michael A Davies
Mar 29, 2012·The Cancer Journal·Diwakar DavarJohn M Kirkwood
Mar 29, 2012·The Cancer Journal·Melissa Wilson, Katherine L Nathanson
Mar 29, 2012·The Cancer Journal·Michael A Davies
Nov 29, 2012·The Cancer Journal·Zhi Ven Fong, Jordan M Winter
Aug 30, 2013·Plastic and Reconstructive Surgery·William W Dzwierzynski
Apr 18, 2012·Genes & Development·Gavin P DunnWilliam C Hahn
Jun 5, 2012·Genes & Development·Hensin TsaoDavid E Fisher
Mar 8, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kathryn BreakerThomas W Flaig
Jun 26, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Doru T AlexandrescuConstantin A Dasanu
May 24, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Barton R JenningsMartin J Phillips
Feb 15, 2012·International Journal of Clinical Practice·R Russell-Jones
Sep 15, 2011·Pigment Cell & Melanoma Research·Pablo Lopez-Bergami
Oct 19, 2011·Pigment Cell & Melanoma Research·Rachel E Bell, Carmit Levy
Mar 14, 2012·Pigment Cell & Melanoma Research·Ha Linh Vu, Andrew E Aplin
Dec 17, 2011·Pigment Cell & Melanoma Research·Wanleng DengMichael A Davies
Jan 18, 2012·Pigment Cell & Melanoma Research·Ken Dutton-Regester, Nicholas K Hayward
Jan 21, 2012·Pigment Cell & Melanoma Research·Vijay WaliaYardena Samuels
Jan 26, 2012·Pigment Cell & Melanoma Research·Jessica L F Teh, Suzie Chen
Feb 18, 2012·Pigment Cell & Melanoma Research·Daniel S WidmerKeith S Hoek
May 26, 2012·Pigment Cell & Melanoma Research·Eric A Collisson
May 15, 2012·Pigment Cell & Melanoma Research·W E Damsky, M Bosenberg
Mar 29, 2012·The Journal of Pharmacology and Experimental Therapeutics·Rajendar K MittapalliWilliam F Elmquist
Sep 3, 2011·Science Translational Medicine·Victor E Velculescu, Luis A Diaz
Dec 3, 2011·Science Translational Medicine·Sameek RoychowdhuryArul M Chinnaiyan
Mar 31, 2012·Science Translational Medicine·John R PrensnerArul M Chinnaiyan
Nov 9, 2012·Science Translational Medicine·Donna M Dambach, Hirdesh Uppal
Mar 31, 2012·Science Translational Medicine·Steven A Rosenberg
Jun 8, 2012·Science Translational Medicine·Steven K SeungWalter J Urba
Apr 5, 2013·Science Translational Medicine·Michael A FischbachWendell A Lim
Aug 2, 2013·Science Translational Medicine·Ryan B CorcoranJeffrey A Engelman
Nov 13, 2012·Gut·Andrew David NelsonJohn S Leeds
Oct 17, 2013·Postgraduate Medical Journal·Ramya RamaswamiThomas Newsom-Davis
Jan 6, 2012·Journal of Skin Cancer·Diwakar DavarJohn M Kirkwood
Dec 17, 2011·Journal of Skin Cancer·Ryan J Sullivan, Keith T Flaherty
Oct 19, 2011·Journal of Skin Cancer·Daniela Göppner, Martin Leverkus
Oct 21, 2011·Dermatology Research and Practice·Ichiro YajimaMasashi Kato
Dec 2, 2011·Cancer Research·J VillanuevaMeenhard Herlyn
Feb 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yingjun SuAnn Richmond
Jun 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Todd D Prickett, Yardena Samuels
Dec 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Muling MaoScott Kopetz
Nov 1, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Theodore P NicolaidesC David James
Nov 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John M KirkwoodReinhard Dummer
Sep 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Evan J Lipson, Charles G Drake
Mar 17, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·George PosteJ Milburn Jessup
May 4, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·E TassiAndrea Anichini
Dec 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antoni RibasJohn M Kirkwood
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael A DaviesKevin Kim
Feb 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kim H T ParaisoKeiran S M Smalley
Feb 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Augusto Villanueva, Josep M Llovet
Jul 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine L NathansonG V Long
May 12, 2012·Cancer Discovery·Matthew J MartinRichard Marais
Jul 17, 2012·Cancer Discovery·Kimberly B DahlmanWilliam Pao
Jan 5, 2013·Cancer Discovery·Steven WhittakerLevi A Garraway
May 10, 2013·Cancer Discovery·Maria Romina Girotti, Richard Marais
May 2, 2012·Onkologie·Sebastian BauerUwe Trefzer
Jun 29, 2012·Case Reports in Oncology·Nicola L SchoenewolfSwiss Group for Clinical Cancer Research (SAKK)
Aug 14, 2012·The Journal of Clinical Investigation·Steven Grant
Apr 2, 2013·The Journal of Clinical Investigation·Ethan V AbelAndrew E Aplin
Mar 5, 2013·The Journal of Clinical Investigation·Deborah A KnightMark J Smyth
Apr 16, 2013·The Journal of Clinical Investigation·Jennifer SchlegelDouglas K Graham
Sep 4, 2012·Therapeutic Advances in Medical Oncology·Damien Kee, John R Zalcberg
Mar 2, 2013·Therapeutic Advances in Medical Oncology·Muhammad KhattakJames Larkin
Dec 10, 2013·Hematology·Sandeep S Dave
Jan 16, 2013·BMC Cancer·Giusy GentilcorePaolo A Ascierto
Apr 17, 2013·BMC Cancer·David J Stewart, Razelle Kurzrock
Dec 10, 2013·BMC Cancer·M IddawelaWilliam R Adam
Apr 27, 2013·BMC Ophthalmology·Alastair K Denniston, Andrew D Dick
May 7, 2013·Molecular Cancer·Carla RozzoMarina Pisano
Jun 15, 2012·Health and Quality of Life Outcomes·Dennis A RevickiSrividya Kotapati
May 30, 2012·Journal of Translational Medicine·Paolo A AsciertoNicola Mozzillo
Dec 12, 2012·Journal of Translational Medicine·Thomas F GajewskiCancer and Leukemia Group B
Mar 22, 2012·Journal of Translational Medicine·Gabriele MadonnaPaolo A Ascierto
May 5, 2012·Journal of Translational Medicine·Paolo A AsciertoNicola Mozzillo
Jun 5, 2013·Journal of Translational Medicine·Paolo A AsciertoMagdalena Thurin
Sep 21, 2013·Journal of Translational Medicine·Aubrey G WagensellerCraig L Slingluff
Feb 14, 2013·Journal of Translational Medicine·Antonio DaponteSouthern Italy Cooperative Oncology Group (SICOG)
Mar 6, 2012·BMC Medicine·Laura FinnRichard W Joseph
Aug 15, 2013·BMC Medicine·Brian GodmanLars L Gustafsson
May 23, 2013·Diagnostic Pathology·Bastian SchillingKlaus G Griewank
Aug 24, 2013·Radiation Oncology·Christopher D LaoBruce G Redman
Apr 17, 2013·BMC Systems Biology·Alexei Vazquez
Feb 16, 2012·Journal of Hematology & Oncology·Byung LeeDelong Liu
Apr 17, 2013·Journal of Hematology & Oncology·Akintunde AkinleyeDelong Liu
Mar 1, 2013·Clinical and Translational Medicine·Charlotte WelinderGyörgy Marko-Varga
Apr 5, 2012·European Journal of Medical Research·Peter Arne GerberBernhard Homey
Nov 21, 2013·Biomarker Research·Chung-Tsen HsuehHong Wang
Dec 1, 2011·Genome Medicine·Chunmei Huang, Jose C Florez
Dec 4, 2012·Genome Medicine·Erika L MoenM Eileen Dolan
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OberholzerLevi A Garraway
Dec 21, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahmad A TarhiniJohn M Kirkwood
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sojun HoshimotoDave S B Hoon
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa ZimmerDirk Schadendorf
Aug 8, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Boris FreidlinEdward L Korn
Jul 10, 2012·The Journal of Clinical Endocrinology and Metabolism·Mingzhao Xing
Feb 4, 2012·Disease Models & Mechanisms·Corina AnastasakiE Elizabeth Patton
May 17, 2012·Annals of Surgical Oncology·Bin B R Kroon
Jul 10, 2012·Annals of Surgical Oncology·Stéphanie MoreauJean-François Emile
Feb 2, 2013·Annals of Surgical Oncology·Carolyn NessimFrances Wright
Feb 9, 2013·Annals of Surgical Oncology·K P Wevers, H J Hoekstra
Mar 21, 2013·Annals of Surgical Oncology·K P WeversH J Hoekstra
Jun 8, 2012·PloS One·Marine ChartrainJean Philippe Annereau
Aug 23, 2012·PloS One·Michelle Barbi de MouraStergios Moschos
Aug 11, 2012·PloS One·Brenden ChenHuifeng Niu
Aug 23, 2012·PloS One·Lucas B MurrayQin Yu
Jan 4, 2013·PloS One·Adam SchayowitzDouglas P Clark
Mar 22, 2013·PloS One·Jeannine D RinderknechtBenedetta Belloni
Sep 29, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Thomas I Peng SohFederico Innocenti
Jan 14, 2012·Endocrine-related Cancer·Maria E Cabanillas, Steven I Sherman
Mar 5, 2013·The Oncologist·Mario E LacoutureA K Joe
Aug 21, 2012·Cancer Management and Research·R A Fisher, J M G Larkin
Jan 8, 2013·Clinical Pharmacology : Advances and Applications·Jung-Ki YoonKevin Kim
Dec 20, 2012·Drug Design, Development and Therapy·Alexander M MenziesRajmohan Murali
Mar 7, 2014·Drug Design, Development and Therapy·Mengna ChiJiezhong Chen
Jan 7, 2014·International Journal of Nanomedicine·Srijayaprakash B UppadaNeelu Puri
Mar 16, 2012·OncoTargets and Therapy·Jose G Monzon, Janet Dancey
Dec 12, 2012·Pharmacogenomics and Personalized Medicine·Jaykumar ThumarHarriet M Kluger
Sep 6, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Gillian M Keating
Feb 24, 2012·Drugs·Raffaele CalifanoPaul Lorigan
Feb 26, 2013·AJR. American Journal of Roentgenology·Richard G AbramsonJeffrey A Sosman
Nov 3, 2011·Future Oncology·Anna MinchomJ M G Larkin
Jul 19, 2013·International Journal of Molecular Sciences·Seema SethiFazlul H Sarkar
Jul 25, 2012·Rare Tumors·Ramon Andrade de Mello
Oct 19, 2011·Future Medicinal Chemistry·Antonio T BainesChanning J Der
Mar 6, 2012·Clinical Neuropathology·David CapperMatthias Preusser
Dec 15, 2012·Chinese Journal of Cancer·Qi-Ming ZhouXiao-Shi Zhang
May 7, 2013·Chinese Journal of Cancer·Li Yan
Jul 3, 2013·Archives of Pathology & Laboratory Medicine·Andrew H FischerMojgan Amrikachi
Sep 3, 2013·Archives of Pathology & Laboratory Medicine·Michael H Roh
Apr 26, 2013·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Rebecca F ChhimMichael L Christensen
Apr 10, 2013·International Journal of Biological Sciences·Junfang JiXin Wei Wang
May 17, 2012·Clinical Medicine : Journal of the Royal College of Physicians of London·Katie E LacyFrank O Nestle
Jun 6, 2014·International Journal of Oncology·Angela RussoMassimo Libra
Apr 12, 2014·British Journal of Cancer·A AzimiCarolina Hertzman Johansson
Oct 24, 2012·Future Medicinal Chemistry·Federico Gago
Jan 24, 2014·BioMed Research International·Dionysis Papadatos-PastosMark Harries
Aug 2, 2013·Future Oncology·Viswanath Reddy BelumUlrich Rodeck
Feb 5, 2014·Future Oncology·Farhad KhimaniGerald M Higa
Dec 24, 2013·Trends in Pharmacological Sciences·Min HuangMeiyu Geng
Jan 2, 2014·Cancer Biotherapy & Radiopharmaceuticals·Robert O DillmanStephanie E McClure
Jul 7, 2012·Future Oncology·William ChoDimitrios H Roukos
Dec 21, 2013·Cancer Immunology, Immunotherapy : CII·Christiane MeyerDaniel E Speiser
Jan 15, 2014·Nature Genetics·Priscilla K BrastianosSandro Santagata
May 8, 2013·Future Oncology·Manolo D'ArcangeloFederico Cappuzzo
Nov 20, 2012·Bioanalysis·Sterghios Athanasios Moschos
Jan 1, 2013·Colorectal Cancer·Bruno Conte, Scott Kopetz
Dec 18, 2013·Pharmacogenomics·Jai N Patel
Jan 16, 2014·Annual Review of Immunology·Marcela V MausCarl H June
Jan 7, 2015·Journal of Personalized Medicine·Howard L KaufmanMichael A Morse
Feb 27, 2014·The Journal of Clinical Investigation·Xiao-Hong MaRavi K Amaravadi
Feb 27, 2014·The Journal of Clinical Investigation·Shirish Shenolikar
Feb 26, 2014·Revue de pneumologie clinique·L GibaultH Blons
Jun 6, 2013·Journal of Skin Cancer·Bartosz Chmielowski
Nov 28, 2013·Annual Review of Medicine·Juliann Chmielecki, Matthew Meyerson
Feb 18, 2014·Current Rheumatology Reports·Julien HarocheZahir Amoura
Dec 22, 2012·Immunotherapy·Orit ItzhakiMichal J Besser
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Ping YuanBin Zheng
Oct 29, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kai ZhangXinjun Guo
Dec 3, 2013·Biochemical Pharmacology·Amanda D Bucheit, Michael A Davies
Dec 3, 2013·Current Oncology Reports·John H Strickler, Herbert I Hurwitz
Feb 25, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mohammad KrayemGhanem Ghanem
Oct 17, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S Martín-AlgarraSpanish Society of Medical Oncology
Oct 8, 2013·Journal of Clinical Pathology·Zandra C DeansDavid Gonzalez
May 31, 2012·Immunotherapy·Mohammed Almubarak, Jame Abraham
Mar 28, 2013·Journal of Skin Cancer·Farid Menaa
Jun 1, 2012·Future Oncology·Samit Patrawala, Igor Puzanov
Feb 25, 2014·Future Oncology·Alison B Durham, Sandra L Wong
Feb 18, 2014·Clinical Medicine : Journal of the Royal College of Physicians of London·Arif Aslam, Christopher E M Griffiths
Feb 11, 2014·Journal of the National Cancer Institute·Klaus G GriewankRajmohan Murali
Apr 17, 2014·Journal of Carcinogenesis·Anthony Jarkowski, Nikhil I Khushalani
Nov 28, 2013·Nature Reviews. Clinical Oncology·Boris Freidlin, Edward L Korn
Dec 20, 2013·Current Treatment Options in Neurology·Nancy U Lin
Dec 12, 2013·Pharmacology & Therapeutics·Carolina Hertzman Johansson, Suzanne Egyhazi Brage
May 29, 2014·Current Treatment Options in Oncology·John C Mavropoulos, Timothy S Wang
May 28, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U Urner-BlochSimone M Goldinger
Apr 30, 2014·Journal of the National Cancer Institute·Chin-Ann Johnny OngRebecca C Fitzgerald
Apr 30, 2014·Journal of the National Cancer Institute·H Ian RobinsRichard B Halberg
Oct 15, 2013·Pharmacology & Therapeutics·Cindy NeuzilletEric Raymond
Dec 17, 2014·Personalized Medicine·Ross A Okimoto, Trever G Bivona
May 13, 2014·Journal of Pharmaceutical and Biomedical Analysis·Jean-Claude AlvarezAdeline Knapp
Mar 7, 2014·Current Treatment Options in Oncology·Ahmed I Megahed, Henry B Koon
Nov 20, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei PengZhi-yu Chen
Jan 29, 2014·European Journal of Cell Biology·Manfred Kunz
Apr 3, 2014·Cellular Oncology (Dordrecht)·Ioannis A Voutsadakis
Jun 1, 2014·Archives of Pathology & Laboratory Medicine·Stefan Kraft, Scott R Granter
Apr 25, 2014·American Journal of Pharmaceutical Education·Christopher L FarrellAmy R Messersmith
Jun 12, 2013·Biochimica Et Biophysica Acta·Simone Mocellin, Donato Nitti
Mar 29, 2014·BMC Research Notes·Elyse K HanlyRaj K Tiwari
Jun 3, 2014·Journal of Skin Cancer·Zhongyun ZhaoBeth Barber
Apr 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J J GrobA Hauschild
Jan 5, 2014·Pharmacology & Therapeutics·Christiane R Maroun, Tracey Rowlands
Jun 4, 2014·Dermatologic Clinics·Robert S Dawe, Sally H Ibbotson
Jun 4, 2013·Oncogene·W E DamskyM Bosenberg
Feb 8, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Samra TurajlicRichard Marais
May 29, 2013·Pharmacology & Therapeutics·Francesca Pretto, Dario Neri
May 7, 2014·Future Oncology·Ewa Aladowicz, Luisa Lanfrancone
May 7, 2014·Future Oncology·Georgios D LianosDimitrios H Roukos
Jun 7, 2013·International Journal of Clinical Oncology·Hisashi UharaRyuhei Okuyama
Feb 27, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C SwantonE Mardis
Jan 5, 2014·Molecular Diagnosis & Therapy·Ewelina NalejskaMarzena Anna Lewandowska
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Luping LinTrever G Bivona
Feb 18, 2014·Annals of Surgical Oncology·Danielle M BelloCharlotte E Ariyan
Jun 8, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Francesca Carlomagno, Mario Chiariello
Jul 18, 2014·Genome Medicine·Jeff Settleman
Mar 12, 2013·ISRN Dermatology·J A Moreno NogueiraR Pérez Temprano
Mar 22, 2014·Current Treatment Options in Oncology·Preetesh JainFarhad Ravandi
Dec 18, 2013·Contemporary Clinical Trials·James X Song
Feb 26, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GuptaM R Middleton
May 9, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Simonetta M Leto, Livio Trusolino
Mar 12, 2013·Cancer Chemotherapy and Pharmacology·Adriana RomitiPaolo Marchetti
Aug 26, 2014·Advances in Therapy·A BerrocalJosé Luis Rodríguez-Peralto
Sep 25, 2014·The New England Journal of Medicine·Stephen John SammutPippa Corrie
Dec 7, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Benjamin GoeppertDavid Capper
Mar 20, 2014·British Journal of Cancer·M HolderfieldD D Stuart
Jul 13, 2014·American Journal of Clinical Dermatology·Lauren BrinJerry D Brewer
Aug 26, 2014·Mutagenesis·El Mustapha Bahassi, Peter J Stambrook
Mar 8, 2014·Molecular Diagnosis & Therapy·Jonathan C DudleyMing-Tseh Lin
Sep 10, 2014·Nature Chemical Biology·Apirat ChaikuadStefan Knapp
Sep 4, 2014·Annual Review of Genomics and Human Genetics·Sameek Roychowdhury, Arul M Chinnaiyan
Sep 23, 2014·Trends in Biochemical Sciences·Chong Sun, R Bernards
May 9, 2014·Thyroid : Official Journal of the American Thyroid Association·Viswanath GundaSareh Parangi
Jul 13, 2014·Journal of Translational Medicine·Nicola Mozzillo, Paolo A Ascierto
Jul 24, 2014·Future Oncology·Miles C AndrewsAndreas Behren
Apr 24, 2014·British Journal of Cancer·S EserD Saur
Aug 3, 2014·Seminars in Oncology Nursing·Debra Wujcik
Jun 30, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrew G RobinsonElizabeth A Eisenhauer
Oct 15, 2013·Oncogene·L DongS T Guo
Nov 3, 2011·Journal of Gastrointestinal Cancer·Samia ArifiHassan Errihani
Aug 22, 2012·Annual Review of Pathology·Gayane Badalian-VeryBarrett J Rollins
Oct 10, 2012·Annual Review of Medicine·Jason T HuseLisa M DeAngelis
Jul 11, 2014·British Journal of Cancer·M V GammonsD O Bates
Aug 19, 2014·The Journal of Molecular Diagnostics : JMD·Grace W WeyantKeri J Donaldson
Nov 1, 2011·Annual Review of Medicine·Keith T Flaherty
Jan 13, 2012·Annual Review of Pharmacology and Toxicology·Timothy A Yap, Paul Workman
Jun 24, 2014·Journal of the American College of Surgeons·Mark FariesAnton J Bilchik
Sep 11, 2014·BMC Research Notes·Saoussane KharmoumHassan Errihani
May 29, 2014·The Journal of Clinical Investigation·Jamie N AnastasRandall T Moon
Jun 5, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Marco RagusaMichele Purrello
Aug 21, 2014·The New England Journal of Medicine·Gauri R Varadhachary, Martin N Raber
Jul 30, 2014·The Journal of Experimental Medicine·Daniel ÖhlundDavid Tuveson
Mar 13, 2014·Cancer Immunology, Immunotherapy : CII·Sander KeldermanChristian Blank
Jun 14, 2014·Current Oncology Reports·Amulya A Nageswara Rao, Roger J Packer
Aug 12, 2014·Biochemical Pharmacology·Vito W Rebecca, Keiran S M Smalley
Jan 10, 2014·Molecular Diagnosis & Therapy·Pedro Madureira, Ramon Andrade de Mello
May 13, 2014·Mayo Clinic Proceedings·Javier MunozRazelle Kurzrock
Jun 26, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·U LeiterClaus Garbe
Nov 6, 2012·Annual Review of Pathology·Fausto J RodriguezCharles G Eberhart
Nov 28, 2013·Actas dermo-sifiliográficas·J R Estela CubellsV Alegre de Miquel
Jan 4, 2012·Acta Neuropathologica·Matthias PreusserAndreas von Deimling
Mar 1, 2014·International Journal of Surgery·K PatelT Ismail
Aug 26, 2014·Future Oncology·Judy W King, Paul Nathan
Jul 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C Gaudy-MarquesteJ J Grob
Jun 15, 2014·American Journal of Clinical Dermatology·Chante KarimkhaniRobert P Dellavalle
Sep 23, 2014·Revue des maladies respiratoires·E BousquetJ Mazieres
Jan 18, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cecilia LezcanoGeorge F Murphy
Nov 13, 2014·The New England Journal of Medicine·Brendan D Curti
Jul 7, 2014·Clinical & Experimental Metastasis·Zied BoudhraaFrançoise Degoul
Sep 24, 2014·The Surgical Clinics of North America·Iris H WeiSandra L Wong
Nov 26, 2013·Biochimica Et Biophysica Acta·Franziska StehleBarbara Seliger
Sep 18, 2014·Current Treatment Options in Oncology·Caroline E McCoach, Robert C Doebele
Jan 26, 2012·Archives of Pathology & Laboratory Medicine·Jeffrey S Ross
Aug 15, 2014·Science Translational Medicine·Nicholas J RobertsShibin Zhou
Jul 23, 2014·Current Opinion in Pharmacology·Sarah J Ross, Susan E Critchlow
Oct 5, 2014·Current Problems in Cancer·Kevin E FisherMichael R Rossi
May 17, 2014·British Journal of Cancer·L HeinzerlingR Schneider-Stock
Jan 13, 2015·BMC Genomics·Lindsay C StetsonJill S Barnholtz-Sloan
Sep 6, 2014·British Medical Bulletin·Pippa CorrieChristine Parkinson
Oct 8, 2014·Nature Reviews. Clinical Oncology·Joel W Neal, George W Sledge
Jul 16, 2014·Familial Cancer·Alexandre Leon Ribeiro de ÁvilaDirce Maria Carraro
Dec 11, 2014·Pharmacogenomics·Edward D EsplinMichael P Snyder
Sep 30, 2014·The New England Journal of Medicine·G V LongKeith T Flaherty
Sep 30, 2014·The New England Journal of Medicine·J M G LarkinAntoni Ribas
Dec 17, 2014·Immunotherapy·Elizabeth C SmythIan Chau
Sep 6, 2014·Journal of Neurosurgery. Spine·Charles G FisherZiya L Gokaslan
Dec 2, 2014·Nature Reviews. Drug Discovery·Ahmed A Samatar, Poulikos I Poulikakos
Oct 1, 2014·British Journal of Cancer·I Vivanco
Nov 20, 2014·The New England Journal of Medicine·Vassiliki A Boussiotis