PMID: 6978340Jan 1, 1982Paper

Improved three-year disease-free survival in osteogenic sarcoma

The Journal of Bone and Joint Surgery. British Volume
W A BleyerJ R Hartmann

Abstract

Of 41 consecutive patients with newly diagnosed osteogenic sarcoma admitted to the Children's Orthopedic Hospital and Medical Center in Seattle, Washington, between 1952 and 1977, 19 treated before 1973 did not receive adjunctive chemotherapy (histological group) whereas after 1972 22 have been so treated (chemotherapy group). Chemotherapy consisted primarily of high doses of methotrexate and adriamycin for 16 months after surgical treatment. Patients in the historical group have been observed for a minimum of nine years (six patients) or until death (13 patients). The 13 surviving patients in the chemotherapy group have been followed for a minimum of three years (median five years) and all 12 disease-free patients have been off therapy for between one and a half and five and a half years (median three years). Overall, the chemotherapy group has had a significant increase in both survival (p = 0.03) and disease-free survival (P = 0.02) compared to the historical group. In 35 patients with localised disease at diagnosis, the three-year disease-free survival and the three-year survival rates were 18 per cent and 41 per cent respectively in the historical group, and 67 per cent and 78 per cent (life table estimates) respectively i...Continue Reading

Citations

Dec 31, 1998·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S J HamH J Hoekstra
Jan 1, 1985·Medical and Pediatric Oncology·C D MitchellR Ellis
Jul 1, 1993·Journal of Surgical Oncology·L Y ShihW H Lo
Aug 1, 1986·Australasian Radiology·I C Dickinson
Jan 1, 1985·Archives of Orthopaedic and Trauma Surgery·S BrooksN M Clarke
May 8, 2001·Cancer Investigation·W S Ferguson, A M Goorin
Sep 24, 2013·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·John S HwangKathleen S Beebe
Apr 1, 1988·Pediatric Annals·C K Tebbi, J Gaeta

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