Sep 13, 2017

Improved Vaccine against PRRSV: Current Progress and Future Perspective

Frontiers in Microbiology
Yuchen NanEn-Min Zhou

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV), one of the most economically significant pathogens worldwide, has caused numerous outbreaks during the past 30 years. PRRSV infection causes reproductive failure in sows and respiratory disease in growing and finishing pigs, leading to huge economic losses for the swine industry. This impact has become even more significant with the recent emergence of highly pathogenic PRRSV strains from China, further exacerbating global food security. Since new PRRSV variants are constantly emerging from outbreaks, current strategies for controlling PRRSV have been largely inadequate, even though our understanding of PRRSV virology, evolution and host immune response has been rapidly expanding. Meanwhile, practical experience has revealed numerous safety and efficacy concerns for currently licensed vaccines, such as shedding of modified live virus (MLV), reversion to virulence, recombination between field strains and MLV and failure to elicit protective immunity against heterogeneous virus. Therefore, an effective vaccine against PRRSV infection is urgently needed. Here, we systematically review recent advances in PRRSV vaccine development. Antigenic variations resulting from PRRSV...Continue Reading

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  • Citations32

References

Mentioned in this Paper

Neutralising Antibodies Analysis
Immune Response
PIGS
Virus
Virus Diseases
Respiratory Tract Diseases
Porcine Reproductive and Respiratory Syndrome
Pathogenic Organism
Vaccines
Chimera Organism

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