Improved vigilance after sodium oxybate treatment in narcolepsy: a comparison between in-field and in-laboratory measurements

Journal of Sleep Research
Mojca K M van SchieRolf Fronczek

Abstract

This two-centre observational study of vigilance measurements assessed the feasibility of vigilance measurements on multiple days using the Sustained Attention to Response Task and the Psychomotor Vigilance Test with portable task equipment, and subsequently assessed the effect of sodium oxybate treatment on vigilance in patients with narcolepsy. Twenty-six patients with narcolepsy and 15 healthy controls were included. The study comprised two in-laboratory days for the Maintenance of Wakefulness Test and the Oxford Sleep Resistance test, followed by 7-day portable vigilance battery measurements. This procedure was repeated for patients with narcolepsy after at least 3 months of stable treatment with sodium oxybate. Patients with narcolepsy had a higher Sustained Attention to Response Task error count, lower Psychomotor Vigilance Test reciprocal reaction time, higher Oxford Sleep Resistance test omission error count adjusted for test duration (Oxford Sleep Resistance testOMIS / MIN ), and lower Oxford Sleep Resistance test and Maintenance of Wakefulness Test sleep latency compared with controls (all P < 0.01). Treatment with sodium oxybate was associated with a longer Maintenance of Wakefulness Test sleep latency (P < 0.01), lo...Continue Reading

References

Jul 1, 1973·Psychophysiology·E HoddesW C Dement
Aug 1, 1982·Human Factors·R T Wilkinson, D Houghton
Sep 1, 1981·Revue d'électroencéphalographie et de neurophysiologie clinique·V Valley, R Broughton
Jun 1, 1997·Journal of Sleep Research·L S BennettR J Davies
Dec 24, 1997·Electroencephalography and Clinical Neurophysiology·K DoghramjiJ M Youakim
Nov 14, 1998·Brain Research. Brain Research Protocols·M de CurtisG Folco
May 17, 2003·Sleep·Sonia Ancoli-IsraelCharles P Pollak
Sep 10, 2004·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Sylvia LohDrew Dawson
Feb 11, 2005·Sleep·Michael R LittnerUNKNOWN Standards of Practice Committee of the American Academy of Sleep Medicine
Feb 11, 2005·Sleep·Donna ArandR Bart Sangal
Apr 25, 2006·Experimental Brain Research·Henry J MollerColin M Shapiro
Dec 15, 2010·European Journal of Endocrinology·Claire E H M DonjacourHanno Pijl
Jun 17, 2011·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Alexandra DimitrovaGert Jan Lammers
Jan 13, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Richard K BoganMaja Miloslavsky

❮ Previous
Next ❯

Citations

Jul 6, 2017·Acta Neurologica Scandinavica·K BolinP Jennum
Dec 13, 2019·Journal of the International Neuropsychological Society : JINS·Pablo Medrano-Martinez, Rosa Peraita-Adrados
Feb 10, 2017·Nature Reviews. Disease Primers·Birgitte R KornumSebastiaan Overeem
Feb 6, 2021·Traffic Injury Prevention·N N J J M van der SluiszenA Vermeeren
Jun 25, 2021·Sleep Medicine Reviews·Marco FilardiGiuseppe Plazzi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.