PMID: 18714670Aug 22, 2008Paper

Improved xenogenic hepatocyte implantation into nude mouse liver parenchyma with acute liver failure when followed by repeated anti-Fas antibody (Jo2) treatment

Cell Transplantation
Isabelle VidalLysiane Richert

Abstract

Hepatocyte transplantation is a promising therapy for acute liver failure in humans. Recently, we succeeded in inducing various acute and chronic liver failures in nude mice. Engraftment of transplanted xenogeneic rat hepatocytes, visualized in the host liver by anti-MHC class I immunohistochemistry, revealed that liver repopulation was limited, and equivalent in nude mice with and without acute liver failure. In the present study, acute liver failure was induced in nude mice by a single injection of sublethal anti-Fas antibody Jo2, followed 24 h later by rat hepatocyte transplantation and than by a weekly repeated injection of Jo2. Rat hepatocyte engraftment into the recipient liver parenchyma 3 weeks following hepatocyte transplantation was about sevenfold increased when nude mice were subsequently subjected to weekly repeated Jo2 injection. Genomic analysis of these mice showed an overall transcriptome profile of upregulation of cellular cycle blocking transcripts, activation of liver injury inducing IFN-gamma/STAT1 pathway, and circadian transcript signature of antiproliferative cell status compared to mice submitted to hepatocyte transplantation only. The findings of the present study suggest that the induction of cell pro...Continue Reading

References

Jun 1, 1999·Seminars in Liver Disease·M GrompeD A Shafritz
Jun 1, 1999·Seminars in Liver Disease·S GuptaP M Novikoff
Sep 15, 1999·Toxicologic Pathology·C KakinumaY Shibutani
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·T C Weglarz, E P Sandgren
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J E GuidottiH Gilgenkrantz
Jan 12, 2002·The American Journal of Pathology·Claudia MitchellHélène Gilgenkrantz
Apr 12, 2002·Laboratory Animals·Pascale DavidLysiane Richert
May 1, 2002·European Journal of Gastroenterology & Hepatology·Hein B A C Stockmann, Jan N M IJzermans
Dec 7, 2002·Seminars in Cell & Developmental Biology·Sanjeev Gupta, Jayanta Roy Chowdhury
Dec 20, 2002·Mechanisms of Development·Nelson Fausto, Jean S Campbell
Aug 23, 2003·Science·Takuya MatsuoHitoshi Okamura
Nov 7, 2003·The Journal of Biological Chemistry·Paul A TownsendAnastasis Stephanou
Aug 10, 2004·World Journal of Gastroenterology : WJG·Min ZhangZhong-Bo Hu
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alvaro Arjona, Dipak K Sarkar
Aug 1, 2006·International Journal of Experimental Pathology·Christian T McCulloughDavid J Harrison
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rui SunBin Gao
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Aezam KatoonizadehTania Roskams
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Brooke H MillerJoseph S Takahashi

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Citations

Nov 30, 2012·International Journal of Hepatology·Isabelle Vidal, Lysiane Richert
Jul 20, 2010·Xenotransplantation·André Gustavo BonavitaLuiz Anastácio Alves
May 8, 2015·Xenotransplantation·Huidong ZhouDavid K C Cooper
Aug 10, 2016·Biochemical and Biophysical Research Communications·Xiaojun HuHong Shan
Jan 1, 2010·Cell Medicine·Luiz Anastácio AlvesRoberto Magalhães Saraiva

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