Improved Y-STR typing for disaster victim identification, missing persons investigations, and historical human skeletal remains.

International Journal of Legal Medicine
Angie AmbersBruce Budowle

Abstract

Bones are a valuable source of DNA in forensic, anthropological, and archaeological investigations. There are a number of scenarios in which the only samples available for testing are highly degraded and/or skeletonized. Often it is necessary to perform more than one type of marker analysis on such samples in order to compile sufficient data for identification. Lineage markers, such as Y-STRs and mitochondrial DNA (mtDNA), represent important systems to complement autosomal DNA markers and anthropological metadata in making associations between unidentified remains and living relatives or for characterization of the remains for historical and archaeological studies. In this comparative study, Y-STR typing with both Yfiler™ and Yfiler™ Plus (Thermo Fisher Scientific, Waltham, MA, USA) was performed on a variety of human skeletal remains, including samples from the American Civil War (1861-1865), the late nineteenth century gold rush era in Deadwood, SD, USA (1874-1877), the Seven Years' War (1756-1763), a seventeenth-century archaeological site in Raspenava, Bohemia (Czech Republic), and World War II (1939-1945). The skeletal remains used for this study were recovered from a wide range of environmental conditions and were extrac...Continue Reading

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Citations

Nov 7, 2019·Journal of Forensic Sciences·Eden Centaine Johnstone-Belford, Soren Blau
Oct 3, 2019·Journal of Forensic Sciences·Michelle Harrel, Sheree Hughes-Stamm
May 18, 2021·Forensic Science International : Synergy·Yanlei LiuShiliang Zhou
Jul 16, 2021·Forensic Science International. Genetics·Michael HofreiterDaniel Vanek
Jul 16, 2021·Human Mutation·Sofie ClaerhoutRonny Decorte
Nov 30, 2018·Analytical Chemistry·Bruce R McCordGeorge Duncan

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