Improvement by sodium dl-α-tocopheryl-6-O-phosphate treatment of moisture-retaining ability in stratum corneum through increased ceramide levels

Bioorganic & Medicinal Chemistry
Eiko Kato, Noriko Takahashi

Abstract

Sodium dl-α-tocopheryl-6-O-phosphate (1), a water-soluble derivative of vitamin E (dl-α-tocopherol, 2), exhibits protective effects against various type of skin damage. As reported herein, we found that topical application of 1 improves hygroscopicity and water holding capacity in the stratum corneum of hairless mice in vivo by increasing the ceramide content. In normal human epidermal keratinocytes, treatment with 1 increases ceramide levels and enhances gene expression of serine palmitoyltransferase, which catalyzes the first step of ceramide synthesis in vitro. In addition, 1 increases gene expressions of differentiation markers (transglutaminase 1, cytokeratin 10, involucrin and loricrin), and intracellular Ca(2+) concentrations. These results suggest that 1 could be an excellent agent for improving skin moisture-retention by enhancing ceramide synthesis through the induction of differentiation.

References

Dec 1, 1990·The Journal of Cell Biology·E Fuchs
Dec 1, 1989·Current Opinion in Cell Biology·F M Watt
Mar 14, 1998·Acta Dermato-venereologica·A Di NardoS Seidenari
Mar 26, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·H KimH Jung

❮ Previous
Next ❯

Citations

Sep 23, 2014·Journal of Dietary Supplements·Majid Ghayour-MobarhanAmirhossein Sahebkar
Dec 28, 2017·International Journal of Molecular Sciences·Tzu-Kai LinJuan Luis Santiago
Aug 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tomonobu UchinoYoshiyuki Kagawa
Sep 22, 2018·International Journal of Toxicology·Monice M FiumeBart Heldreth
Jul 16, 2019·RSC Advances·Janet P YaporMelissa M Reynolds
Nov 1, 2020·International Journal of Pharmaceutics·Tomonobu UchinoYoshiyuki Kagawa
Oct 19, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Cheryl Wei Ling TeoWei Ney Yap

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.