Abstract
Patients with severe haemophilia A (HA) receive factor VIII (FVIII) replacement therapy as prophylaxis. myPKFiT® is an online medical application that allows authorized users to simulate dosing regimens with patient pharmacokinetic (PK) profiles based on only 2 blood samples. Our aim was to assess the impact of using this medical device in routine practice in terms of FVIII consumption and clinical outcomes. Thirty-six patients with severe HA on prophylaxis with Advate® were recruited in 3 centres in Spain. Annual bleeding rate (ABR), annual joint bleeding rate (AJBR) and annual FVIII consumption before and after adjustment were obtained using the patient's clinical history (12 months before) and prospectively recorded data (12 months after), respectively. Adjustment was based on PK parameters provided by myPKFiT® , joint status and relative risk associated with physical activity and bleeding phenotype. ABR and AJBR were significantly reduced after adjustment in the overall sample (-2.2 ± 1.3, P = .018 and -1.9 ± 1.2, P = .012, respectively) and in patients aged >15 years (-2.6 ± 1.4, P = .011 and -2.0 ± 1.2, P = .005, respectively). Adjustment had an effect on the individual FVIII consumption of most patients: annual amount wa...Continue Reading
References
Jan 16, 2009·Journal of Thrombosis and Haemostasis : JTH·P W CollinsUNKNOWN rAHF-PFM Study Group
Apr 20, 2010·Journal of Thrombosis and Haemostasis : JTH·S BjörkmanP W Collins
Nov 2, 2011·Blood·Sven BjörkmanPeter W Collins
Jun 29, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·P W Collins
Jul 11, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SrivastavaUNKNOWN Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia
Oct 11, 2012·JAMA : the Journal of the American Medical Association·Carolyn R BroderickSimon A Brown
Apr 10, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A Valentino
Apr 26, 2014·Haemophilia : the Official Journal of the World Federation of Hemophilia·K FischerC M Kessler
Jan 21, 2015·Expert Review of Hematology·Pia PetriniBruce Ewenstein
Feb 26, 2015·Blood·Johannes Oldenburg
Mar 15, 2015·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·María E Mingot-CastellanoAnabel I Heiniger-Mazo
Nov 28, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·J LockUNKNOWN 'OPTI-CLOT' study group
Jul 16, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·M García-DasíJ Barbero
Nov 30, 2016·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sergio IannazzoAlessandro Gringeri
Jan 12, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·M T Álvarez-RománV Jiménez-Yuste
Jul 12, 2017·Thrombosis Research·Samantha PascaEzio Zanon
Oct 19, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·K KhairA Gringeri
Citations
Mar 14, 2019·Haemophilia : the Official Journal of the World Federation of Hemophilia·Juan Eduardo Megías-VericatJosé Luis Poveda
Jul 13, 2019·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jenny Y ZhouAnnette von Drygalski
Jun 4, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Steven W Pipe
Sep 19, 2019·Journal of Medical Economics·Anisha M PatelRobert F Sidonio
May 12, 2020·Frontiers in Pharmacology·Rachel J TysonDaniel Gonzalez
Mar 23, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Alexandros ArvanitakisJan Astermark
Mar 30, 2021·Pediatric Investigation·Zhenping ChenRunhui Wu
Jan 29, 2021·Thrombosis and Haemostasis·Victor S BlanchetteJan Blatny
Jul 23, 2021·Thrombosis Research·Juan Eduardo Megías-VericatJose Luis Poveda