Improvement in depression and health-related quality of life after sacral nerve stimulation therapy for treatment of voiding dysfunction

Urology
Anurag K DasU.S. MDT-103 Study Group

Abstract

To assess depression and health-related quality of life (HRQOL) in 89 people with refractory urge incontinence, nonobstructive urinary retention, or urgency frequency enrolled at 13 U.S. study centers. The subjects were part of a large international, multicenter, randomized clinical trial on the safety and efficacy of sacral nerve stimulation for the treatment of refractory voiding dysfunction. The Beck Depression Index and the Medical Outcomes Study Short-Form 36 were used to assess depression and HRQOL at baseline and at two follow-up visits. Detectable levels of depression and reduced quality of life were noted at baseline. Subjects implanted with the stimulation device reported significant improvements in both HRQOL and depression at 3 months after implant that were maintained for the 6-month study period. Subjects assigned to the delayed implant group showed a slight worsening of HRQOL and depression from baseline to 3 months that continued through the 6-month visit. The results demonstrated the serious impact that unresolved voiding symptoms have on the physical, social, and psychological dimensions of quality of life. Treating refractory voiding dysfunction with sacral nerve stimulation resulted in improvement in both de...Continue Reading

Citations

Oct 26, 2010·International Urogynecology Journal·Philip E V Van Kerrebroeck
Jun 13, 2014·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Edmond P H ChoiWeng-Yee Chin
Dec 10, 2009·International Urogynecology Journal·Lone MouritsenGunnar Lose
Sep 8, 2010·Current Urology Reports·Ravi Kacker, Anurag K Das
Jun 6, 2009·International Urogynecology Journal and Pelvic Floor Dysfunction·Megan O SchimpfPaul K Tulikangas
Mar 20, 2012·International Urogynecology Journal·Ash K MongaJeyakumar Subbaroyan
Nov 20, 2012·International Urogynecology Journal·Amie KawasakiCindy L Amundsen
Nov 5, 2013·The Urologic Clinics of North America·Ravi KackerAnurag Das
Feb 19, 2008·Urology·Yu-Hua FanKuang-Kuo Chen
Dec 26, 2007·Urology·Sherif R AboseifMichael H Ree
Jan 9, 2007·Best Practice & Research. Clinical Obstetrics & Gynaecology·Shing-Kai Yip, Linda Cardozo
Jun 15, 2007·Neurourology and Urodynamics·Dennis J A J Oerlemans, Philip E V van Kerrebroeck
Apr 27, 2010·Neurourology and Urodynamics·Nazema Y SiddiquiCindy L Amundsen
Sep 13, 2005·Best Practice & Research. Clinical Obstetrics & Gynaecology·Lawrence O Olujide, Suzanne M O'Sullivan
Dec 17, 2014·Journal of Psychosomatic Research·Desiree VrijensCarsten Leue
Apr 28, 2012·Urologia Internationalis·A C van VoskuilenP E V van Kerrenbroeck
Jan 13, 2012·Urologia·Emilio SaccoPierfrancesco Bassi
Nov 13, 2008·Nature Clinical Practice. Urology·Thomas M Kessler, Clare J Fowler
Oct 20, 2012·Health Economics, Policy, and Law·Daniel Callahan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Urology
Ananias C DioknoDavid B Konstandt
International Urogynecology Journal and Pelvic Floor Dysfunction
Blair B Washington, Brian J Hines
© 2022 Meta ULC. All rights reserved