Improvement in Depressive Symptoms Is Associated with Reduced Oxidative Damage and Inflammatory Response in Type 2 Diabetic Patients with Subsyndromal Depression: The Results of a Randomized Controlled Trial Comparing Psychoeducation, Physical Exercise, and Enhanced Treatment as Usual

International Journal of Endocrinology
Marijana Vučić LovrenčićNorbert Hermanns

Abstract

Aims. To examine one-year changes in oxidative damage and inflammation level in type 2 diabetic patients undergoing behavioral treatment for subsyndromal depression. Materials and Methods. A randomized controlled comparison of psychoeducation (A), physical exercise (B), and enhanced treatment as usual (C) was performed in 209 eligible subjects in a tertiary diabetes care setting. Depressive symptoms (primary outcome) and selected biomarkers of oxidative damage and inflammation (secondary outcomes) were assessed at baseline and six- and twelve-month follow-up. Results. Out of the 74, 67, and 68 patients randomised into groups A, B, and C, respectively, 201 completed the interventions, and 179 were analysed. Participants in all three groups equally improved in depressive symptoms from baseline to one-year follow-up (repeated measures ANOVA; F = 12.51, p < 0.0001, η (2) = 0.07). Urinary 8-oxo-deoxyguanosine (u-8-oxodG) decreased (F = 10.66, p < 0.0001, η (2) = 0.06), as did sialic acid and leukocytes (F = 84.57, η (2) = 0.32 and F = 12.61, η (2) = 0.07, resp.; p < 0.0001), while uric acid increased (F = 12.53, p < 0.0001, η (2) = 0.07) in all subjects during one year. Improvement of depressive symptoms at 6 months significantly pr...Continue Reading

References

Jul 1, 1997·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M VucićS J Ashcroft
Nov 14, 1997·The American Journal of Psychiatry·P RohdeJ R Seeley
Aug 4, 2001·Psychosomatic Medicine·M de GrootP J Lustman
Oct 30, 2003·Medical Care·Kurt KroenkeJanet B W Williams
Nov 18, 2003·Acta Diabetologica·K L KellerM S Faith
Jun 24, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L M BrowningJ D Krebs
Mar 23, 2005·American Journal of Epidemiology·Xuanping ZhangHenry S Kahn
Feb 2, 2006·Psychosomatic Medicine·Michael J Forlenza, Gregory E Miller
Apr 21, 2006·Clinical Biochemistry·Karina P Gopaul, Martin A Crook
Oct 24, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·S AliK Khunti
Jan 15, 2008·Metabolism: Clinical and Experimental·Hideki NojimaUNKNOWN Hiroshima University Health Promotion Study Group
Apr 17, 2008·Journal of Diabetes and Its Complications·Mirjana Pibernik-OkanovicUNKNOWN European Depression in Diabetes Research Consortium
Dec 9, 2008·General Hospital Psychiatry·Lisa K RichardsonMulugeta Gebregziabher
Oct 19, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·Mariska BotPeter de Jonge
Jan 5, 2011·Psychotherapy·Christopher F Sharpley
Feb 4, 2011·Epidemiologic Perspectives & Innovations : EP+I·Joseph H Abramson
Mar 9, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S de KortA A M Masclee
Aug 9, 2011·Free Radical Biology & Medicine·Kasper BroedbaekHenrik E Poulsen
Apr 25, 2012·Annals of the New York Academy of Sciences·Ajit Varki, Pascal Gagneux
Jun 13, 2012·Diabetologia·A T Turer, P E Scherer
Jun 27, 2012·Psychiatry Research·Siyan YiTetsuya Mizoue
Jul 26, 2012·Experimental Diabetes Research·Rebecca Hutcheson, Petra Rocic
Aug 29, 2012·Oxidative Medicine and Cellular Longevity·Edite Teixeira de LemosFlávio Reis
Mar 16, 2013·Psychoneuroendocrinology·Kirstin AschbacherElissa Epel
May 3, 2013·Asia Pacific Journal of Clinical Nutrition·Mark L Wahlqvist
Jun 6, 2013·Diabetes Care·Lawrence FisherLisa A Strycker
Jun 25, 2013·Biochimica Et Biophysica Acta·Henrik E PoulsenAllan Weimann
Sep 26, 2013·Diabetes·Richard J JohnsonMiguel A Lanaspa
Dec 12, 2013·Molecular Metabolism·Sudarshana Purkayastha, Dongsheng Cai
Dec 18, 2013·Psychosomatic Medicine·Priya PaltaSarah L Szanton
Mar 5, 2014·Current Diabetes Reviews·Shokoufeh Bonakdaran, Banafsheh Kharaqani
Mar 13, 2014·Psychosomatic Medicine·Nicolas Rohleder
May 7, 2014·Diabetes Research and Clinical Practice·Nathalie EsserNicolas Paquot

❮ Previous
Next ❯

Citations

Sep 28, 2017·The Cochrane Database of Systematic Reviews·Boon How ChewGuy Ehm Rutten
Nov 7, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Naveen ShivavediPrasanta Kumar Nayak
Jun 22, 2021·International Journal of Environmental Health Research·Luciano Acordi da SilvaPaulo Cesar Silveira

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
ELISAs

Software Mentioned

SPSS
DIAMOS

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.