Improvement in early symptoms of shock by delayed intestinal protease inhibition

Archives of Surgery
Florian FitzalGeert W Schmid-Schönbein

Abstract

Recent findings indicate that intraintestinal pancreatic protease inhibition before superior mesentery artery occlusion (SMAO) attenuates inflammation and symptoms of shock. Herein we examine the effectiveness of delayed intestinal protease inhibition during reperfusion after SMAO. Three groups of male Wistar rats were studied: a nonshock sham group and 2 groups exposed to SMAO for 100 minutes and treated by delayed intestinal lavage starting 40 minutes after reperfusion with buffer (delayed-lavage group) or with the digestive protease inhibitor gabexate mesilate (FOY) (delayed FOY-lavage group). Arterial pressure during reperfusion was significantly lower in the delayed-lavage animals compared with the sham group. Superior mesentery artery occlusion and reperfusion caused the formation of leukocyte activation factors in intestinal homogenates and in plasma, as well as intestinal injury. The delayed-lavage group had a significant increase in activated leukocytes in venules of cremaster muscle. In contrast, in the delayed FOY-lavage group, lavage 40 minutes after reperfusion led to a significant improvement of blood pressure and decreased formation of intestine-derived leukocyte activation factors and intestinal injury compared ...Continue Reading

Citations

Dec 13, 2007·World Journal of Surgery·Anubhav MittalJohn A Windsor
Jan 25, 2013·Science Translational Medicine·Frank A DeLanoGeert W Schmid-Schönbein
Apr 10, 2012·Transplantation Proceedings·Y-T LeeG W Schmid-Schönbein
Nov 28, 2007·International Immunopharmacology·Geert W Schmid-Schönbein
Feb 19, 2008·Cardiology in Review·William H FrishmanGrigory Rozenblit
Sep 11, 2009·The Journal of Trauma·Darren J MalinoskiDavid B Hoyt
Aug 31, 2013·Annals of Biomedical Engineering·Geert W Schmid-Schönbein, Marisol Chang
Dec 31, 2015·Shock·Angelina E AltshulerGeert W Schmid-Schönbein

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