Improvement in endothelial progenitor cells from peripheral blood by ramipril therapy in patients with stable coronary artery disease

Cardiovascular Drugs and Therapy
Tao Qian MinShang Yun Peng

Abstract

The aim of this study is to investigate whether angiotensin-converting enzyme inhibitor (ACEI) therapy with ramipril could augment circulating endothelial progenitor cells (EPCs) with enhanced functional activity in patients with stable coronary artery diseases. 20 patients with angiographically documented stable coronary artery disease (CAD) were prospectively treated with 5 mg of ramipril per day for 4 weeks. Before and weekly after the initiation of ramipril therapy, EPCs were isolated from peripheral blood and counted. Ramipril treatment of patients with stable CAD was associated with an approximately 1.5-fold increase in the number of circulating EPCs by 1 week after initiation of treatment; this was followed by sustained increased levels to approximately 2.5-fold throughout the 4-week study period. In addition, ramipril treatmen was associated with increases in the functional activity of EPCs, as assessed by their proliferation, migration, adhesion and in vitro vasculogenesis capacity. The results of the present study define a novel mechanism of action of ACEI treatment in patients with stable CAD: the augmentation of circulating EPCs with enhanced functional activity. Given the well-established role of EPCs of participat...Continue Reading

Citations

Sep 22, 2010·Basic Research in Cardiology·Janine PössUlrich Laufs
May 20, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Giuseppe MandraffinoAntonino Saitta
Jun 24, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio Imanishi
Dec 17, 2005·Antioxidants & Redox Signaling·Cindy J M LoomansAnton-Jan Van Zonneveld
Aug 18, 2010·Antioxidants & Redox Signaling·Felix Fleissner, Thomas Thum
Mar 21, 2009·European Heart Journal·Antonio Maria LeoneFilippo Crea
Jan 12, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrzej SurdackiJacek S Dubiel
Sep 5, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrzej SurdackiJacek S Dubiel
Nov 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ferdinand H BahlmannDanilo Fliser
May 16, 2009·Nephrology·Michael S GoligorskyMarianne C Verhaar
Mar 20, 2010·Journal of Angiogenesis Research·Aurangzeb SiddiqueChetan Varma
Oct 6, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Akio KuroiTakashi Akasaka
Aug 16, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio ImanishiIchiro Nishio
Aug 31, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Katsunobu KobayashiTakashi Akasaka
Jul 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio ImanishiTakashi Akasaka
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Fuyong DuXiao-Feng Yang
Jul 29, 2009·Journal of Endocrinological Investigation·A ZeoliM F Brizzi
May 8, 2014·International Journal of Inflammation·Maricica PacurariKenneth Ndebele
Dec 17, 2009·European Journal of Clinical Pharmacology·Natália AntónioLuís A Providência
Jan 18, 2006·Endothelium : Journal of Endothelial Cell Research·N AlobaidG Hamilton
Dec 16, 2006·Endothelium : Journal of Endothelial Cell Research·Michel R HoenigJulie H Campbell
Jun 22, 2010·Expert Opinion on Biological Therapy·Soo Jeong ChoiSeung Duk Hwang
Apr 24, 2009·Climacteric : the Journal of the International Menopause Society·F PellicciaG Rosano
Feb 8, 2011·Current Opinion in Pharmacology·Anton J M RoksThomas Walther
Aug 31, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Mohamad Amer AlaitiMarco A Costa
Jul 14, 2010·Transplantation Proceedings·N TownamchaiS Eiam-Ong
Oct 1, 2008·International Journal of Cardiology·Giulio PompilioPaolo Biglioli
Sep 22, 2007·Progress in Neurobiology·Bertrand LapergueAshfaq Shuaib
Sep 17, 2008·Journal of Surgical Oncology·Markus BrunnerBoban M Erovic
Jun 27, 2006·Journal of Cellular and Molecular Medicine·N Werner, G Nickenig
Feb 2, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Robert A Taylor, Adnan I Qureshi
Jul 28, 2011·Journal of Neuroscience Research·Huijie WeiJianning Zhang
Jun 27, 2009·Journal of Cellular and Molecular Medicine·Martin SteinmetzSven Wassmann
Jun 21, 2006·The American Journal of Cardiology·Carlos M Ferrario, William B Strawn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.