Improvement in muscle strength after an anterior cruciate ligament injury corresponds with a decrease in serum cytokines

Cytokine
Tyler BarkerRoy H Trawick

Abstract

The purpose of this communication was to identify if a decrease in serum cytokine concentrations associates with an improvement in muscle strength after an anterior cruciate ligament (ACL) injury. To establish groups with contrasting serum cytokine concentrations, subjects scheduled for ACL reconstructive surgery were separated into one of two groups (gender matched) based on their time from injury occurrence: (1) Early (<21-d from injury occurrence; n=22) or (2) Late (⩾21-d from injury occurrence; n=22). Before surgery, each subject provided a fasting blood sample and performed single-leg peak isometric force testing on the injured (INJ) and non-injured (NI) limbs. Compared to the NI limb, peak isometric force in the INJ limb was decreased (p<0.05) in both groups (Early, ∼35%; Late, ∼18%). The deficit in peak isometric force, however, was increased (p<0.05) in the Early compared to Late group. Similarly, serum granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6, and IL-13 were increased (all p<0.05) in the Early group. These unique findings show a concurrent increase in muscular weakness and serum cytokine concentrations shortly after (<21-d) an ACL injury. Importantly, muscular weakness persisted the...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J D MorrowL J Roberts
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·P A KernG Ranganathan
May 2, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marjolein VisserTamara B Harris
Nov 16, 2004·Journal of Applied Physiology·F HaddadG R Adams
Dec 6, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Paul H Marks, Michelle L Cameron Donaldson
Jun 6, 2006·The American Journal of Medicine·Laura A SchaapMarjolein Visser
Oct 22, 2009·Redox Report : Communications in Free Radical Research·Tyler BarkerMaret G Traber

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