Improvement in Psoriasis Signs and Symptoms Assessed by the Psoriasis Symptom Inventory with Brodalumab Treatment in Patients with Psoriatic Arthritis

The Journal of Rheumatology
Philip MeaseAjay Nirula

Abstract

To evaluate the effect of brodalumab on psoriasis signs and symptoms assessed by the Psoriasis Symptom Inventory (PSI) in patients with psoriatic arthritis (PsA). This prespecified analysis of a phase II study (NCT01516957) evaluated patients with active PsA and psoriasis-affected body surface area ≥ 3%, randomized to brodalumab (140 or 280 mg) or placebo every 2 weeks (Q2W) for 12 weeks with loading dose at Week 1. At Week 12, patients entering an open-label extension received brodalumab 280 mg Q2W. The PSI measures 8 psoriasis signs and symptoms: itch, redness, scaling, burning, stinging, cracking, flaking, and pain. PSI response is defined as total PSI ≤ 8 (range 0-32), each item ≤ 1 (range 0-4). PSI scores were assessed at weeks 12 and 24. There were 107 eligible patients. At Week 12, mean improvement in PSI scores was 7.8, 11.2, and 1.5 in brodalumab 140 mg, 280 mg, and placebo groups, respectively; by Week 24, improvement was 10.2, 12.4, and 11.7. At Week 12, 75.0%, 81.8%, and 16.7% of patients receiving brodalumab 140 mg, 280 mg, and placebo, respectively, achieved PSI response; improvement was sustained through Week 24, when 83.9% of prior placebo recipients achieved response. At Week 12, 25.0%, 36.4%, and 2.8% of patie...Continue Reading

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References

Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Feb 15, 2005·Annals of the Rheumatic Diseases·D D GladmanP Nash
Oct 4, 2005·Journal of the American Academy of Dermatology·Joel M GelfandTara Rolstad
Sep 20, 2006·The Journal of Experimental Medicine·Spencer C LiangLynette A Fouser
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Spencer C LiangLynette A Fouser
Jan 18, 2008·The Journal of Investigative Dermatology·Michelle A LowesJames G Krueger
May 27, 2008·Journal of Autoimmunity·Valérie DardalhonAna C Anderson
Jul 11, 2008·Immunological Reviews·Laura A TesmerDavid A Fox
Oct 28, 2008·Annals of the Rheumatic Diseases·C T RitchlinUNKNOWN Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
Apr 17, 2010·The Journal of Rheumatology·Philip J MeaseChiun-Fang Chiou
Jun 29, 2010·Arthritis and Rheumatism·Jan LeipeAlla Skapenko
Sep 7, 2011·Molecular and Cellular Biochemistry·Siba P RaychaudhuriMark C Genovese
Mar 20, 2012·Seminars in Arthritis and Rheumatism·Stefan W H DandorferMatthias Englbrecht
Mar 30, 2012·The New England Journal of Medicine·Kim A PappScott Baumgartner
May 1, 2012·International Journal of Rheumatology·Shinji MaedaRyuzo Ueda
Oct 25, 2012·The Journal of Dermatological Treatment·Donald M BushnellGregory Kricorian
Dec 5, 2012·Arthritis·Peter LloydAlan Menter
Jan 24, 2013·The Journal of Dermatological Treatment·Dennis A RevickiHema N Viswanathan
Mar 16, 2013·Current Opinion in Rheumatology·Philip Mease
Aug 29, 2013·Journal of the American Academy of Dermatology·Philip J MeaseDaniel Alvarez
Nov 30, 2013·Arthritis Research & Therapy·Helen BenhamHill Gaston
Jun 12, 2014·The New England Journal of Medicine·Philip J MeaseAjay Nirula

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Citations

Apr 15, 2020·Dermatologic Therapy·Paola FacherisAntonio Costanzo
Jun 9, 2016·Expert Opinion on Therapeutic Patents·Andrea ChiricozziMaria Sole Chimenti
Jan 11, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Kiana Maryam Vakil-GilaniAtul Deodhar
Sep 20, 2018·The Journal of Dermatology·Hideki FujitaUNKNOWN Japanese Dermatological Association Guidelines Development Committee for the Guidelines for the Management and Treatment of
Mar 17, 2016·Expert Opinion on Biological Therapy·Jürgen BraunUta Kiltz
Nov 8, 2017·Expert Review of Clinical Immunology·Jillian FriederAlan Menter
Sep 1, 2016·Drugs·Sarah L Greig

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