Improvement of anger at one week predicts the effects of sertraline and placebo in PTSD

Journal of Psychiatric Research
Jonathan DavidsonCathryn M Clary

Abstract

In previous work we demonstrated an early, robust and sustained effect for sertraline vs placebo on irritability and anger in subjects with PTSD. In this report, we explore the same dataset to assess whether a clinician might usefully predict ultimate response to sertraline, on the basis of its effect upon anger after one week. Three hundred and eighteen subjects were assessed. Outcome was measured by whether or not the score was reduced by at least 50% from baseline. Ordinary least squares regression was used to estimate the effects of change in anger at one week. Logistic regression was applied to estimate the effects on odds of a 50% drop in score. Cut points were developed for one-week change scores on anger for sertraline and placebo. The best cut point was selected as predictive of non-response, i.e. a cue suggesting that treatment switch would be in order. An increase in anger of 30% at one-week best predicted the likelihood of not responding to treatment in both the drug and placebo groups. Twenty-five percent of all non-responders were incorrectly identified, while only 7% of all improvers were incorrectly categorized as non-responders using this cutoff. Our findings imply that, for patients similar to those in this st...Continue Reading

References

Jan 1, 1995·Journal of Traumatic Stress·D D BlakeT M Keane
Jun 1, 1993·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·H H StassenJ Angst
Jan 1, 1997·Psychological Medicine·J R DavidsonM E Feldman
Apr 19, 2000·JAMA : the Journal of the American Medical Association·K BradyG M Farfel
Jul 10, 2002·Psychological Medicine·J R T DavidsonC M Clary
Aug 23, 2002·Journal of Psychiatric Research·Mark H PollackCathryn M Clary

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Citations

Aug 16, 2005·Current Psychiatry Reports·Damiaan Denys, Femke de Geus
Sep 18, 2012·Journal of Psychiatric Research·Alline Cristina CamposFrancisco Silveira Guimarães
Aug 29, 2006·Biological Psychiatry·Ann M RasmussonAlessandro Guidotti
May 17, 2006·Journal of Clinical Psychopharmacology·Jonathan DavidsonJeff J Musgnung
May 28, 2019·Behavioral Sciences·Ángel Romero-MartínezLuis Moya-Albiol

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