Improvement of Aspects of Subjective Sleep Quality of Healthy Volunteers by Ingestion of Porcine Placental Extract: A Randomized Cross-Over Pilot Study

Frontiers in Nutrition
Mahiko NagaseYasuhiko Komatsu

Abstract

Objectives: This study assessed the effects of oral porcine placental extract (PPE) on sleep quality of healthy volunteers not satisfied with their sleep. Design: This study used a randomized, placebo-controlled, double-blind, cross-over clinical pilot study. Setting: This study was conducted under an outpatient multicenter setting in Japan. Interventions: A total of 20 healthy Japanese volunteers aged between 28 and 73, whose Pittsburgh Sleep Quality Index global scores were between 6 and 10, successfully completed the study. At first, PPE at 300 mg/kg or placebo was ingested for 2 weeks. Then, after a 2-week washout period, each group ingested under a cross-over setting the opposite sample (placebo or PPE) for another 2 weeks. Main Outcome Measures: Objective measurement of the sleep made with an activity tracker and subjective measurements of sleep quality by use of St. Mary's Hospital Sleep Questionnaire were done just before and after the administration time slots. Results: No effect of PPE on the sleep length was observed. Several measures in the subjective St. Mary's Hospital Sleep Questionnaire, i.e., changes in Q5 (sleep depth) and Q9 (sleep wellness) between pre- and post-ingestions, were significantly different betwe...Continue Reading

References

Aug 1, 1988·The American Review of Respiratory Disease·L J FindleyP M Suratt
Jul 17, 1997·Nature·D Dawson, K Reid
Apr 17, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nelson B PowellChristian Guilleminault
Jan 18, 2003·Sleep Medicine Reviews·Avi Sadeh, Christine Acebo
Sep 20, 2006·Archives of Internal Medicine·Kristen L KnutsonEve Van Cauter
Jan 18, 2011·Sleep Medicine Reviews·Avi Sadeh
Oct 29, 2011·Sleep Medicine·Sherry A BeaudreauUNKNOWN Study of Osteoporotic Fractures
Aug 28, 2012·Climacteric : the Journal of the International Menopause Society·K KoikeM Inoue
Sep 10, 2014·SpringerPlus·Yukihiko ItoMakoto Satoh
Oct 7, 2016·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Katarina AiliLena Hillert
Jan 24, 2017·Climacteric : the Journal of the International Menopause Society·M KitanoharaM Nagase

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