Improvement of atopic dermatitis with topical application of Spirodela polyrhiza

Journal of Ethnopharmacology
Hye Ji LeeWoong Mo Yang

Abstract

Spirodela polyrhiza has been used as a traditional remedy for the treatment of urticarial, acute nephritis, inflammation, as well as skin disease. Atopic dermatitis (AD) is characterized hyperplasia of skin lesion and increase of serum immunoglobulin E (IgE) level. In this study, the topical effects of S. polyrhiza (SP) on 2, 4-dinitrochlorobenzene (DNCB)-induced AD mice model were investigated by several experiments. BALB/c mice were randomly divided into five groups as NOR, CON, DEX, SP 1, and SP 100 groups (n=5, respectively). To induce atopic dermatitis-like skin lesions, DNCB had been applied on shaved dorsal skin. SP was topically treated to DNCB-induced mice as 1 and 100mg/mL concentrations. Histological changes were showed by hematoxylin and eosin (H&E) staining and the infiltration of mast cells was detected by toluidine blue staining. In addition, the level of IgE and each cytokines were measured and expressions of inflammatory signaling factors were analyzed by western blotting assay. SP treatment improved a hyperplasia of epidermis and dermis in DNCB-induced AD-like skin lesion. The infiltration of mast cells was also decreased by treatment of SP. In addition, SP reduced the level of IgE in serum and attenuated the ...Continue Reading

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K TurksenE Fuchs
Sep 1, 1995·The British Journal of Dermatology·H AoyamaH Tagami
Jun 5, 2003·Clinics in Dermatology·Nordwig S Tomi, Thomas A Luger
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Jonathan M Spergel, Amy S Paller
Jun 22, 2005·Journal of the American Academy of Dermatology·James Del Rosso, Sheila Fallon Friedlander
Dec 17, 2008·The Journal of Investigative Dermatology·Haoli JinRaif S Geha
Aug 12, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sang-Hyun Kim, Tae-Yong Shin
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Kelly D StoneDean D Metcalfe
Aug 7, 2010·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Toshio Hirano
Aug 27, 2010·The Journal of Investigative Dermatology·Tatyana E ShawEric L Simpson
Mar 25, 2011·The Journal of Investigative Dermatology·So Young KimSoo Young Choi
Oct 14, 2011·Journal of Clinical & Cellular Immunology·Eric B Brandt, Umasundari Sivaprasad
Nov 25, 2011·Respiratory Medicine·Kawa Amin
Feb 7, 2012·Immunopharmacology and Immunotoxicology·Chang-Seob SeoHyeun-Kyoo Shin
Dec 1, 2012·Journal of Ethnopharmacology·Gabsik YangHo-Young Choi
Feb 15, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gun-Dong KimCheung-Seog Park

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Citations

Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oludemi TaofiqIsabel C F R Ferreira
Jun 27, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun Jong KimWoo Kyung Kim
Jun 27, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Ruth Mery LópezEnrique Fernando Castillo
Jun 20, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Huan YangHua Wang
Aug 29, 2018·The American Journal of Chinese Medicine·Hyun Jong KimWoo Kyung Kim

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