PMID: 8466346Apr 1, 1993Paper

Improvement of cardiac function impaired by repeated ischemic arrests in isolated rat hearts

The Annals of Thoracic Surgery
K AliY Furukawa

Abstract

We investigated the effects of coenzyme Q10 and verapamil, either alone or in combination, on cardiac function impaired by repeated ischemic arrests and reperfusion in the isolated rat heart. In the group with a single ischemic arrest, the aortic flow, cardiac output, stroke volume, coronary flow, and heart rate recovered well (72% to 100% of the prearrest values). In the repeated-arrest group, the recovery of aortic flow (24%), cardiac output (30%), stroke volume (40%), or coronary flow (63%) was much poorer than that in the single-arrest group. Pretreatment with coenzyme Q10 given intraperitoneally improved aortic flow, cardiac output, stroke volume, coronary flow, and heart rate. The addition of verapamil to the reperfusion solution also protected the cardiac function with a decrease in heart rate. However, combination therapy with coenzyme Q10 and verapamil further increased the recoveries of aortic flow, cardiac output, stroke volume, and coronary flow to 57%, 61%, 77%, and 84%, respectively, which were better than the values after treatment with coenzyme Q10 or verapamil alone. We, therefore, suggest that treatment with coenzyme Q10 or verapamil, alone or in combination, in addition to St. Thomas' Hospital solution effect...Continue Reading

References

Jul 1, 1978·Journal of Molecular and Cellular Cardiology·D J HearseG R Bullock
Jul 1, 1985·Journal of the American College of Cardiology·B Hammond, M L Hess
Apr 1, 1972·The American Journal of Cardiology·D A CooleyD C Wukasch
Jan 1, 1982·Journal of Molecular and Cellular Cardiology·H OhharaM Nakamura
Jan 1, 1981·Journal of Molecular and Cellular Cardiology·H OhharaM Nakamura
Apr 1, 1981·Journal of Molecular and Cellular Cardiology·W G Nayler, P M Grinwald
Jul 1, 1980·Journal of Molecular and Cellular Cardiology·D J HearseS M Humphrey
Aug 15, 1980·Experientia·S SugiyamaY Izawa

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Citations

Jan 5, 2002·European Journal of Pharmacology·Roger J LegtenbergPaul Smits
Oct 7, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Neeti MakhijaRansi Abraham

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