Improvement of cardiopulmonary exercise capacity in patients with obstructive sleep apnea syndrome under CPAP therapy

Medizinische Klinik
Barbara Monika SchlosserHans-Werner Duchna

Abstract

Obstructive sleep apnea syndrome (OSAS) is regarded as a cardiovascular risk factor. Therefore, cardiopulmonary exercise capacity in patients with OSAS before and under treatment with continuous positive airway pressure (CPAP) was investigated. Cardiopulmonary exercise capacity was investigated in 36 patients with untreated OSAS using spiroergometry. A follow-up after at least 6 months was performed in 17 of these patients being treated with CPAP and in eight CPAP-neglecting patients, who served as controls. Maximum oxygen uptake ( <V(.)>O(2max)) was significantly reduced in all 36 patients with untreated OSAS (17.68 +/- 6.1 ml/min/kg) compared with reference values (30.72 +/- 4.9 ml/min/kg; p < 0.001). After an average of 305.7 +/- 104.8 nights of CPAP therapy, <V(.)>O(2max) rose from 15.33 +/- 4.8 to 18.53 +/- 6.9 ml/min/kg, whereas <V(.)>O(2max) remained unchanged in controls. Further spirometric parameters of exercise capacity as well as arterial blood pressure were also significantly improved under CPAP therapy. Cardiopulmonary exercise capacity is markedly reduced in patients with OSAS. Long-term CPAP therapy leads to a significant improvement of reduced cardiopulmonary exercise capacity in these patients.

Citations

May 14, 2014·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kyriaki G CholidouManos Alchanatis
Dec 21, 2006·Der Internist·K RascheH W Duchna
Mar 27, 2015·Annals of Saudi Medicine·Ilker OzsaracAyten Filiz
Jun 10, 2009·International Journal of Cardiology·Mehmood ButtGregory Y H Lip

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