Improvement of cutaneous delivery of methylene blue by liquid crystals

International Journal of Pharmaceutics
Maria Teresa Junqueira GarciaLuciana Biagini Lopes

Abstract

The purpose of this study was to evaluate the effect of composition and characteristics of liquid crystalline phases (LCPs) on cutaneous delivery of methylene blue (MB). LCPs were obtained by mixing Brij97® with water at various ratios; Brij97®:water at 8:2 (F8:2), 7:3 (F7:3), and 6:4 (F6:4) were selected, and MB was incorporated at 0.1%. F8:2 and F7:3 exhibited textures and small angle X-ray scattering (SAXS) patterns corresponding to lamellar phase, whereas F6:4 displayed characteristics of hexagonal phase. All three LCPs were stable for 9 months, and exhibited thixotropic pseudoplastic behaviour. Increasing water content increased viscosity. All three LCPs released less (3.2- to 6.6-fold) MB than control gel (3.0% hydroxyethylcellulose (HEC) + 0.1% MB), demonstrating their ability to sustain release. Despite the lower release, all LCPs improved skin retention of MB at 6 h post-application (1.3- to 2.1-fold) compared to the control gel. Among the LCPs, F8:2-mediated skin retention of MB was more pronounced, followed by F7:3. Consistent with the increased penetration, transepidermal water loss (TEWL) also increased after treatment with the LCPs (2.0-2.8 fold), which suggests their influence on skin barrier. Irritation studies ...Continue Reading

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Citations

Oct 5, 2019·Current Pharmaceutical Design·Federica CarducciLeandro Ramos Souza Barbosa
Sep 5, 2020·Expert Opinion on Drug Delivery·Ana Vitoria Pupo SilvestriniMaria Vitoria Lopes Badra Bentley
Apr 1, 2021·Journal of Biomedical Nanotechnology·Giovana Maria Fioramonti CalixtoMarlus Chorilli
Jul 28, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maria Tereza Carneiro Paschoal BernardesFlávia Chiva Carvalho
Oct 8, 2021·Pharmaceutical Development and Technology·Celia Maria Vargas da Costa BuzzoAlexsandra Conceição Apolinário

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