Improvement of cytocompatibility of polylactide by filling with marine algae powder

Materials Science & Engineering. C, Materials for Biological Applications
Tung-Yi WuYi-Chiang Hsu

Abstract

This work evaluated the cytocompatibility, thermal and mechanical properties of composites of polylactide (PLA) and marine algae powder (MAP). To improve the thermal and mechanical properties of PLA-MAP composites, glycidyl methacrylate (GMA) was used as the compatibilizer for the blending of PLA and MAP. The PLA-g-GMA/MAP composites exhibited superior mechanical properties, attributing to higher compatibility between the polymer and MAP, comparing to PLA/MAP composites. The dispersion of MAP in the PLA-g-GMA matrix was highly homogeneous as a result of etherification. The lower melt torque of the PLA-g-GMA/MAP composites also made them more processable than PLA/MAP. To assess the cytocompatibility, normal human foreskin fibroblasts (FBs) were seeded onto each type of the composites. Results of FB proliferation, collagen production, and cytotoxicity assays indicated greater cytocompatibility for the PLA/MAP composites than for the PLA-g-GMA/MAP composites. Furthermore, both PLA/MAP and PLA-g-GMA/MAP composites were more cytocompatible than pure PLA.

References

Feb 14, 2007·Journal of Agricultural and Food Chemistry·Yi-Hsuan ChenGow-Chin Yen
Feb 15, 2011·Journal of the Mechanical Behavior of Biomedical Materials·A C VieiraA T Marques
May 29, 2012·Biotechnology Advances·Song QinPeng Jiang
Sep 3, 2013·International Journal of Biological Macromolecules·Dai-Hung Ngo, Se-Kwon Kim
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Hao-Yang MiLih-Sheng Turng
Jun 17, 2014·Biomaterials·Victor Hernandez-Gordillo, Jean Chmielewski

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