Improvement of diabetic complication by hydrangea dulcis folium in streptozotocin-induced diabetic rats

Biological & Pharmaceutical Bulletin
Hye Kyung KimDong Hoon Shin

Abstract

The improvement of diabetic complications such as lipid lowering and anti-oxidative potential of Hydrangea Dulcis Folium (HDF) was studied in streptozotocin-induced diabetic rats. Male Sprague-Dawley rats were divided into 3 groups after induction of streptozotocin (STZ)-diabetes: normal control; diabetic control; diabetic-HDF supplement (hot water extract 40 g/kg diet); and fed experimental diets for 3 weeks. Serum glucose and insulin concentrations, serum lipid profile, intraperitoneal glucose tolerance test, and liver cytosolic antioxidant enzyme levels were measured. The HDF supplement significantly decreased serum glucose concentration, increased insulin level, and improved glucose homeostasis in diabetic control rats. The total cholesterol and triglyceride concentrations in the serum and liver were markedly reduced by HDF treatment in STZ-diabetic rats. Moreover, low density lipoprotein (LDL)-, VLDL-, and high density lipoprotein (HDL)-cholesterol levels were ameliorated in HDF supplemented diabetic rats. Decreased fecal excretions of cholesterol, triglyceride, and bile acid in diabetic rats were significantly increased by HDF consumption. HDF supplement reversed the effects of the oxidative stress system of liver in diab...Continue Reading

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Citations

Sep 1, 2011·Journal of Medicinal Food·Maricelma da Silva Soares de SouzaVinícius Castrequini Donda
Apr 23, 2010·Biological & Pharmaceutical Bulletin·Kyohei TakahashiYoshiko Tampo
Apr 28, 2009·Vascular Pharmacology·Mehrdad Roghani, Tourandokht Baluchnejadmojarad
Dec 5, 2009·Phytotherapy Research : PTR·Tourandokht BaluchnejadmojaradZeynab Khastehkhodaie

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