Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease

Journal of the American College of Cardiology
Christian HeissYerem Yeghiazarians

Abstract

In patients with coronary artery disease (CAD) medically managed according to currently accepted guidelines, we tested whether a 1-month dietary intervention with flavanol-containing cocoa leads to an improvement of endothelial dysfunction and whether this is associated with an enhanced number and function of circulating angiogenic cells (CACs). Dietary flavanols can improve endothelial dysfunction. The CACs, also termed endothelial progenitor cells, are critical for vascular repair and maintenance of endothelial function. In a randomized, controlled, double-masked, cross-over trial, 16 CAD patients (64+/-3 years of age) received a dietary high-flavanol intervention (HiFI [375 mg]) and a macronutrient- and micronutrient-matched low-flavanol intervention (LoFI [9 mg]) twice daily in random order over 30 days. Endothelium-dependent vasomotor function, as measured by flow-mediated vasodilation of the brachial artery, improved by 47% in the HiFI period compared with the LoFI period. After HiFI, the number of CD34+/KDR+-CACs, as measured by flow cytometry, increased 2.2-fold as compared with after LoFI. The CAC functions, as measured by the capacity to survive, differentiate, proliferate, and to migrate were not different between th...Continue Reading

Associated Clinical Trials

Nov 6, 2007·Yerem Yeghiazarians

References

Aug 24, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stefanie Dimmeler, Andreas M Zeiher
May 3, 2005·Journal of the American College of Cardiology·Christian HeissChristoph Kalka
Sep 9, 2005·The New England Journal of Medicine·Nikos WernerGeorg Nickenig
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hagen SchroeterMalte Kelm
Feb 20, 2007·Journal of the American College of Cardiology·Eduard ShantsilaGregory Y H Lip
Feb 22, 2007·Journal of Cardiovascular Pharmacology·Christian HeissHelmut Sies
Mar 18, 2009·Circulation·Roberto CortiThomas F Lüscher
Nov 17, 2009·Nature Chemical Biology·Jon O LundbergEddie Weitzberg

❮ Previous
Next ❯

Citations

Sep 7, 2011·Current Atherosclerosis Reports·Owais KhawajaLuc Djoussé
Jun 12, 2012·Current Hypertension Reports·Isabella SudanoGeorg Noll
Oct 21, 2011·Genes & Nutrition·Sebastian Schaffer, Barry Halliwell
Jul 8, 2011·The British Journal of Nutrition·Damian O McCallJayne V Woodside
Mar 9, 2012·The British Journal of Nutrition·Ana Rodriguez-MateosJeremy P E Spencer
Apr 9, 2013·Nutrition Research Reviews·C F HaskellD O Kennedy
Apr 8, 2011·Antioxidants & Redox Signaling·David L KatzAther Ali
Sep 21, 2010·European Heart Journal·Christian HeissMalte Kelm
Jul 27, 2012·Journal of Cardiovascular Pharmacology·Israel Ramirez-SanchezFrancisco Villarreal
Aug 31, 2011·BMJ : British Medical Journal·Adriana Buitrago-LopezOscar H Franco
May 7, 2013·Annual Review of Nutrition·Samantha Ellam, Gary Williamson
Jan 7, 2011·American Journal of Physiology. Cell Physiology·Israel Ramirez-SanchezFrancisco Villarreal
Sep 10, 2011·Journal of Applied Physiology·Kevin D MonahanMary E J Lott
Apr 15, 2015·Vascular Pharmacology·Gurvinder RullRoger Corder
May 23, 2012·Nitric Oxide : Biology and Chemistry·Matthias TotzeckTienush Rassaf
Jun 15, 2011·Maturitas·L Fernández-MurgaA Cano
May 8, 2013·Molecular Nutrition & Food Research·Sara ArranzRamon Estruch
Jul 1, 2015·Journal of Agricultural and Food Chemistry·Claudio FerriDavide Grassi
Sep 9, 2015·The British Journal of Nutrition·Roberto SansoneUNKNOWN Flaviola Consortium, European Union 7th Framework Program
Oct 31, 2015·The Journal of Clinical Hypertension·Agnes Jumar, Roland E Schmieder
Dec 3, 2014·Redox Biology·Ruslan RafikovStephen M Black
May 28, 2015·Age·Christian HeissUNKNOWN FLAVIOLA Consortium, European Union 7th Framework Program
May 20, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Roberto SansoneChristian Heiss
Oct 11, 2011·Free Radical Biology & Medicine·Robert J Williams, Jeremy P E Spencer
Mar 13, 2012·Free Radical Biology & Medicine·Christian HeissTienush Rassaf
Oct 21, 2014·Antioxidants & Redox Signaling·Christian HeissMalte Kelm
Nov 23, 2012·International Journal of Cardiology·Emeline M Van CraenenbroeckViviane M Conraads
May 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B A R LinaP P Tenning
Sep 22, 2010·Molecular Aspects of Medicine·Hagen SchroeterHarold H Schmitz
Nov 7, 2014·The British Journal of Nutrition·Rebecca B CostelloChristopher T Sempos
Apr 28, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Bethan E PhillipsKenneth Smith
Jul 29, 2016·The British Journal of Nutrition·Dragana DjuricaCarl L Keen
Jul 2, 2016·Phytotherapy Research : PTR·Julia VlachojannisSigrun Chrubasik-Hausmann
Jun 23, 2016·Molecular Nutrition & Food Research·James I DowerPeter C H Hollman
Jun 2, 2017·Nutrition Research Reviews·Jacklyn JacksonMark McEvoy
May 3, 2018·Journal of the American College of Nutrition·Yousef A Al-DashtiRobert M Hackman
Apr 26, 2017·The Cochrane Database of Systematic Reviews·Karin RiedNigel P Stocks

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.