Improvement of exercise-induced cardiac deformation after cell therapy for severe chronic ischemic heart failure

Journal of Cardiac Failure
Frederic LebrunDaniel R Wagner

Abstract

Intracoronary infusion of autologous bone marrow cells (CTX) has been shown to improve myocardial function in postinfarct patients and in patients with chronic ischemic cardiomyopathy. Whether CTX affects exercise-induced changes in cardiac deformation and mitral regurgitation (MR) in patients with end-stage heart failure has not been studied. In this small pilot study, 11 patients with chronic ischemic cardiomyopathy, ejection fraction (EF) <25%, no inducible ischemia and heart failure class New York Heart Association (NYHA) III underwent CTX. Symptom-limited bicycle exercise echocardiography was performed pre- and 4 months post-CTX and maximum systolic strain (msyepsilon), peak systolic strain rate (psysr), and effective regurgitant orifice of MR (ERO) were determined. There were no complications related to the procedure. The overall clinical benefit of CTX was limited with a trend towards improvement (NYHA 3.0 +/- 0.1 pre- and 2.7 +/- 0.2 post-CTX, P = .06). The EF did not improve after CTX. The wall motion score index did not change at rest but decreased significantly during exercise (1.48 +/- 0.16 versus 1.44 +/- 0.17, P = .01). In patients with non-viable areas, msyepsilon, psysr, and ERO were not affected by CTX. However...Continue Reading

References

Jan 5, 2002·The New England Journal of Medicine·Federico QuainiPiero Anversa
Dec 10, 2003·Journal of the American College of Cardiology·Patrizio LancellottiLuc A Piérard

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Citations

Jun 19, 2010·Journal of Cardiovascular Translational Research·Eric Fuh, Todd J Brinton
Jun 16, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·R A Argyle, S G Ray
Jul 18, 2019·Journal of Tissue Engineering and Regenerative Medicine·Bas R van KlarenboschArco J Teske

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