Improvement of health-related quality of life in relapsing remitting multiple sclerosis patients after 2 years of treatment with intramuscular interferon-beta-1a.

Journal of Neurology
Peter J JongenFunctional composite and quality of Life in Avonex-treated Relapsing multiple sclerosis patients study group

Abstract

In patients with relapsing remitting multiple sclerosis (RRMS), the effect of interferon-beta (INFb) on health-related quality of life (HR-QoL) is not firmly documented. The objective of this study is to assess HR-QoL during 2 years of treatment with intramuscular INFb and its correlation with disability. In 36 neurological practices in the Netherlands (17), Belgium (16), United Kingdom (2) and Luxemburg (1), 284 RRMS patients were treated with intramuscular INFb-1a. Physical and mental domains of HR-QoL were measured by the MS54 Quality of Life (MS54QoL) questionnaire, and disability was assessed by the Multiple Sclerosis Functional Composite (MSFC) (Timed 25-Foot Walk Test [Timed 25-FWT], 9 Hole Peg Test [9-HPT], Paced Auditory Serial Addition Test [PASAT]) at baseline and at months 3, 6, 12, 18 and 24. Expanded Disability Status Scale (EDSS) score was assessed at baseline and month 24. Pearson's correlation coefficients were determined and predefined factors were analyzed for relation to HR-QoL after baseline by stepwise regression analyses on physical and mental scores. 204 patients (71.8%) completed 2 years of treatment. Mean values for MS54QoL increased from 56.6 to 61.0 for physical (p < 0.05) and from 57.2 to 61.1 for m...Continue Reading

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Citations

Nov 3, 2011·PloS One·Peter Joseph JongenUNKNOWN Functional Composite and Quality of Life in Avonex-treated Relapsing Multiple Sclerosis Patients Study Group
Jul 26, 2014·International Journal of MS Care·Bonnie I GlanzBrian C Healy
Dec 2, 2011·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T JenischM A Gamulescu
Jun 7, 2015·NeuroImage·Kunio NakamuraUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 25, 2015·Psychiatry and Clinical Neurosciences·Naghmeh MokhberMahmoud Reza Azarpazhooh
Aug 12, 2016·Journal of Research in Pharmacy Practice·Nahid HatamRahil Sadat Shahtaheri
Jan 29, 2017·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Diana L Vargas, William R Tyor
Mar 22, 2021·Archives of public health = Archives belges de santé publique·Laurenske A VisserWilliam K Redekop

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