Improvement of hemodialysis catheter function with tenecteplase: a phase III, open-label study: TROPICS 4.

Journal of Thrombosis and Thrombolysis
Steven FishbaneSusan M Begelman

Abstract

Hemodialysis (HD) catheters are prone to thrombotic occlusion. We evaluated tenecteplase, a thrombolytic, for the treatment of dysfunctional HD catheters. Patients with tunneled HD catheters and blood flow rate (BFR) <300 mL/min received open-label tenecteplase (2 mg/lumen) for a 1 h intracatheter dwell. Treatment success was defined as BFR ≥ 300 mL/min and a ≥ 25 mL/min increase from baseline BFR, 30 min before and at the end of HD. Patients without treatment success at the end of the initial visit received another 2 mg dose of tenecteplase for an up to 72 h extended dwell. Of 223 enrolled patients, 34% (95% confidence interval [CI], 28-40%) had treatment success after a 1 h dwell. Mean (standard deviation [SD]) BFR change from baseline was 82 (124) mL/min. Treatment success in those who received extended-dwell tenecteplase (n = 116) was 49% (95% CI, 40-58%), with mean (SD) BFR change from baseline of 117 (140) mL/min. Reported targeted adverse events included five catheter-related bloodstream infections and one thrombosis. No intracranial hemorrhage, major bleeding, embolic events, or catheter-related complications were reported. Tenecteplase administered as a 1 h or 1 h plus extended dwell was associated with improved HD cat...Continue Reading

References

Nov 1, 1991·Journal of Vascular and Interventional Radiology : JVIR·M C BrunnerS C Jensik
Sep 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A H MossD E McDowell
Feb 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S J SchwabD L Stickel
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·B A KeytJ Ogez
Jun 1, 1993·Journal of the American Society of Nephrology : JASN·Z J TwardowskiJ D Haynie
Sep 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P V SuhockiS J Schwab
Aug 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P N PrabhuE A Ross
May 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Z J Twardowski
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P DaeihaghM Rocco
Oct 30, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M A LittleJ J Walshe
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mark A Little, J Joseph Walshe
Aug 9, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Heather EyrichAndrew Howe
Dec 31, 2002·The Annals of Pharmacotherapy·James M ZachariasLavern M Vercaigne
Feb 18, 2003·Pharmacotherapy·Daniel E HillemanKathleen A Packard
Feb 7, 2004·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Lynne SenécalMartine Leblanc
Feb 18, 2004·Clinical Nephrology·A FalkJ A Vassalotti
Oct 19, 2004·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Timothy V Nguyen, Margaret Dikun
Apr 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Oluwatoyin F BamgbolaJoseph T Flynn
Sep 30, 2005·Hemodialysis International·Jennifer Marie MacraeMercedeh Kiaii
Mar 23, 2006·The Journal of Vascular Access·J HaymondJ Jastrzebski
Feb 6, 2010·Clinical Journal of the American Society of Nephrology : CJASN·James TumlinSusan M Begelman

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Citations

Jul 5, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Vandana Dua Niyyar, Micah R Chan

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