Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin

Chemico-biological Interactions
Chun-Ping LuTzu-Hua Wu

Abstract

Macrophages and inflammasome pathway are involved in high-glucose toxicity and development of insulin resistance. Silymarin (SMR) was known to modulate glucose homeostasis and reduce inflammation. However, it is still unknown whether SMR possess anti-hyperglycemic effects in diabetic-like knockout mice (Hnf-1αkin/-/Ins.cre mice) with insulin resistance and also unclear how SMR regulates LPS induced stress markers and pro-inflammatory cytokines under stresses of high glucose (HG) or NLRP3 inflammasome activation. Current results show that oral administration of SMR (100 mg/kg) reduced hyperglycemia in the mouse model of maturity-onset diabetes of the young type 3-like mice. In cultured macrophages, SMR (5-20 μg/ml) reduces high glucose (HG)-enhanced expressions of inducible nitric oxide synthase, nitric oxide generation stimulated by LPS; however, no effects on COX-2 expressions. The enhanced interleukin-1β (ΙL-1β) secretions in the presence of HG or palmitate were also significantly down regulated by SMR in dose-dependent manner in LPS-treated macrophages. Such observations may result from the decreased extracellular signal-regulated kinase 1/2 phosphorylation, while without affecting protein kinase C-α phosphorylation and nucl...Continue Reading

Citations

Mar 7, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Fernanda Caetano Camini, Daniela Caldeira Costa
Jul 25, 2019·Chinese Medicine·Zhengrong ZhangGuoqi Zhu
Dec 15, 2019·Biomolecules·Sujuan DingJun Fang
Nov 27, 2021·Phytotherapy Research : PTR·Fahimeh Zamani-GarmsiriReza Meshkani

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