Improvement of impaired microcirculation and tissue oxygenation by hemodilution with hydroxyethyl starch plus cell-free hemoglobin in acute porcine pancreatitis

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Marc FreitagTim Strate

Abstract

To avoid the progression from mild edematous acute pancreatitis (AP) to the severe necrotizing form, one therapeutic option is to improve pancreatic microcirculation and tissue oxygenation. The aim of the study was to evaluate the influence of improved rheology (isovolemic hemodilution) plus enhanced oxygen supply (bovine hemoglobin HBOC-301) on pancreatic microcirculation, tissue oxygenation and survival in severe acute experimental pancreatitis. Severe AP was induced in 39 pigs (25-30 kg BW) by stimulation with intravenous administration of cerulein plus a pressure- and volume-controlled 10-min intraductal infusion of glycodeoxycholic acid. Seventy-five minutes after induction of AP, animals were randomized and hemodiluted isovolemically (PAOP constant) with either 10% hydroxyethyl starch (HES) 200,000/0.5 plus HBOC-301 (+0.6 g/dl plasmatic hemoglobin; Oxyglobin, Biopure, Cambridge, Mass., USA), or 10% HES 200,000/0.5, or Ringer's solution to a hematocrit of 15%. Hemodynamics, oxygen transport parameters, pancreatic microcirculation and tissue oxygen tension were evaluated over 6 h. Then the abdomen was closed, animals were extubated and observed for 6 days. After that, the surviving animals were sacrificed and specimens were...Continue Reading

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Citations

Apr 20, 2013·World Journal of Gastroenterology : WJG·Gang ZhaoChun-You Wang
Feb 8, 2014·Critical Care : the Official Journal of the Critical Care Forum·Daniel Harper, Clare E McNaught
Dec 10, 2013·Critical Care : the Official Journal of the Critical Care Forum·Kai A BachmannOliver Mann
Feb 4, 2011·Medical Hypotheses·Sayed Mahdi MarashiZeynab Nasri Nasrabadi
Aug 18, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Oliver MannTim Strate
Apr 7, 2009·Gastroenterology·Bechien U WuPeter A Banks
Jul 16, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Timothy B GardnerSuresh T Chari
May 16, 2007·ANZ Journal of Surgery·John C PapakostasMiltiadis I Matsagas
Jan 7, 2015·World Journal of Gastroenterology : WJG·Aakash AggarwalRakesh Kochhar
Dec 22, 2010·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Françoise ArnaudDaniel Freilich
Jan 2, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hiromi SakaiEishun Tsuchida

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